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Flashcards in Odontogenic Cysts and Tumors Deck (61):
1

the most common developmental odontogenic cyst; originates secondary to the separation of the follicle from the crown of an unerupted tooth; enlargement occurs secondary to increased osmotic pressure within the lumen of the cyst

dentigerous cyst

2

M>F; 2nd and 3rd decades; mandibular 3rd molars most common, followed by maxillary canines; typically asymptomatic or a painless expansion; unilocular radiolucency; affected tooth may by displaced; may see root resorption of adjacent teeth

dentigerous cyst

3

soft tissue counterpart to the dentigerous cyst; occurs within the soft tissue overlying the alveolar bone

eruption cyst

4

under 10 years; typically involves mandibular molars; soft, translucent swelling of the gingival mucosa overlying an unerupted tooth

eruption cyst

5

traditionally, defined as a cyst that develops in place of a missing tooth; most are histologically diagnosed as odontogenic keratocyst

primordial cyst

6

distinct odontogenic cyst with specific histologic features and clinical behavior; arises from cell rests of the dental lamina; also associated with nevoid basal cell carcinoma syndrome

odontogenic keratocyst

7

M>F; 10-40 years; mandible>Maxilla; rarely cause expansion; unilocular to multilocular radiolucency

odontogenic keratocyst

8

not necessarily a clinical type of cyst, but an odontogenic cyst that microscopically has an orthokeratinized lining; markedly different clinical behavior from the odontogenic keratocyst

orthokeratinized odontogenic cyst

9

nonspecific; M>F; young adults; most involve the mandibular third molars; stratified squamous epithelium that exhibits a prominent layer of orthokeratin

orthokeratinized odontogenic cyst

10

autosomal dominant syndrome secondary to mutations in the patched (PTCH) tumor suppressor gene; high penetrance and variable expressivity; features multiple basal cell carcinomas of skin, odontogenic keratocysts, rib and vertebral anomalies, and intracranial calcifications

nevoid basal cell carcinoma syndrome (gorlin syndrome)

11

frontal and temporoparietal bossing; ocular hypertelorism; multiple and early basal cell carcinomas; palmar/plantar pitting; bifid ribs and other skeletal anomalies; calcified falx cerebri; multiple odontogenic keratocysts

nevoid basal cell carcinoma syndrome

12

superficial, keratin-filled cysts on the alveolar mucosa; arise from remnants of the dental lamina; similar in appearance (although not location) to Epstein's pearls and Bohn's nodules

gingival cyst of the newborn

13

maxilla>mandible; multiple small papules on the alveolar processes of neonates

gingival cyst of the newborn

14

soft tissue counterpart of the lateral periodontal cyst; derived from rests of the dental lamina; 5th-6th decade; mandibular canine-premolar area; blue to blue-gray dome-shaped swelling

gingival cyst of the adult

15

Developmental (not inflammtory) cysts that typically occurs along the lateral root surface; probably arises from rests of the dental lamina

lateral periodontal cyst

16

M>F; over age 30; mandibular canine-premolar area; well circumscribed radiolucency lateral to the root of a vital tooth (multilocular=botyroid)

lateral periodontal cyst

17

uncommon cyst, sometimes associated with other odontogenic tumors; if no cystic component is present, epithelial odontogenic ghost cell tumor or deninogenic ghost cell tumor is more appropriate

calcifying odontogenic cyst

18

avg. age 33; maxilla=mandible, often involving the maxillary incisor-canine region; may be peripheral; unilocular radiolucency, often with radiopaque structures within the lesion; most lesions are 2-4 cm; may see root resorption or divergence

calcifying odontogenic cyst

19

rare odontogenic cyst that shows features of glandular differentiation; also referred to as sialo-odontogenic cyst; the pathogenesis of this lesion is unknown; adults, mandible; strong predilection for the anterior portions of the jaws; may cross the midline

glandular odontogenic cyst

20

larger lesions capable of bony expansion; well-defined unilocular or multilocular radiolucency with a sclerotic rim; "hobnail" appearance to the luminal epithelial cells

glandular odontogenic cyst

21

may arise de novo or from malignant transformation of a pre-existing cyst or neoplasm; must rule out the possibility of metastatic carcinoma

carcinoma arising in odontogenic cysts

22

M>F, older patients; pain, swelling, parasthesia; irregular, ragged radiolucency

carcinoma arising in odontogenic cysts

23

the most common of the odontogenic epithelial neoplasms; arises from odontogenic epithelium

ameloblastoma

24

M=F, avg, age 34; asymptomatic swelling and expansion; posterior mandible; multilocular radiolucency, often associated with an unerupted tooth; resorption of roots is common

conventional ameloblastoma

25

ameloblastoma _ variant: predilection for anterior regions of jaws; radiographic resemblance to fribro-osseous lesions

desmoplastic

26

_ pattern of ameloblastoma: islands of epithelium resembling the enamel organ with peripheral palisading and reverse polarity; central area resembling stellate reticulum

follicular

27

_ pattern of ameloblastoma: anastomosing cords or sheets of cells; peripheral palisading and reverse polarity

plexiform

28

_ pattern of ameloblastoma: squamous metaplasia within the tumor islands; keratin formation with occasional keratin pearls

acanthomatous

29

_ pattern of ameloblastoma: cells within the islands are characterized by a granular cytoplasm

granular cell

30

_ pattern of ameloblastoma: small islands and cords of odontogenic epithelium; dense fibrous stroma

desmoplastic

31

_ pattern of ameloblastoma: nests of basaloid cells; peripheral islands more cuboidal than columnar

basal cell

32

controversy regarding its definition; some feel that the lesion must be unilocular; others believe that multilocular is acceptable if the internal aspect is cystic; 10-15% of intraosseous ameloblastomas; previously thought less aggressive lesion with significantly lower recurrence rate, but this has recently been disputed

unicystic ameloblastoma

33

younger patients; mandible, usually posterior; asymptomatic or painless swelling; circumscribed radiolucency

unicystic ameloblastoma

34

uncommon variant; probably arises from submucosal rests of odontogenic epithelium or from the basal layer of the surface epithelium

peripheral ameloblastoma

35

middle aged patients; painless gingival swelling; posterior mandible; may superficially erode bone, but overall no radiographic evidence of intraosseous lesion

peripheral ameloblastoma

36

cytologically malignant ameloblastoma

ameloblastic carcinoma

37

cytologically benign lesion showing metastasis

malignant ameloblastoma

38

avg. age 30; metastatic site primarily the lungs, often after 10 years

malignant ameloblastoma

39

sixth decade; ill-defined, destructive lucency

ameloblastic carcinoma

40

uncommon tumor of uncertain histogenesis; thought to arise from stratum intermedium of enamel organ; other theories of histogenesis include rests of the dental lamina; posterior mandible; adults; painless, slow-growing swelling

calcifying epithelial odontogenic tumor

41

often associated with impacted tooth; unilocular to multilocular; radiolucent, with or without "driven-snow" radiopacities; amyloid (congo red positive); Liesegang rings

calcifying epithelial odontogenic tumor

42

benign odontogenic tumor that arises either from rests of the dental lamina of the rests of Malassez; the tumor tends to originate from within the periodontal ligament; probably diagnosed previously as a variant of ameloblastoma or even squamous cell carcinoma

squamous odontogenic tumor

43

M=F, avg, age 38; painless or slightly painful swelling; mobility of associated teeth; triangular radiolucency; SOT-like proliferations

squamous odontogenic tumor

44

originally included in the variants of ameloblastoma; thought derived from the enamel organ epithelium or possible remnants of the dental lamina; may produce dentinoid material, rarely enamel matrix

adenomatoid odontogenic tumor

45

F>M; Most occur during the second decade; anterior maxilla; large lesions cause a painless expansion; circumscribed radiolucency involving the crown of an unerupted tooth; extends beyond the CEJ; may contain "snowflake" calcifications

adenomatoid odontogenic tumor

46

thick fibrous capsule; aggregates of spindle shaped cells frequently in a whorled arrangement; variable numbers of duct-like structures; may contain small foci of calcification

adenomatoid odontogenic tumor

47

mixed odontogenic tumor with both neoplastic epithelial and mesenchymal tissues; many of these may actually represent early developing odontomas

ameloblastic fibroma

48

M>F, first 2 decades; posterior mandible; many associated with an unerupted tooth; unilocular or multilocular radiolucency

ameloblastic fibroma

49

mesenchymal tissue resembling the dental papilla (pulp); odontogenic epithelium in islands or cords; epithelial portion resembles developing enamel organ

ameloblastic fibroma

50

most common odontogenic tumor; two types: compound and complex

odontoma

51

first 2 decades; large painless expansion; may see ghost cells

odontoma

52

_ odontoma: posterior maxilla or mandible; calcified mass with the density of tooth structure

complex

53

_ odontoma: anterior maxilla; multiple tooth-like structures with radiolucent rim

compound

54

uncommon lesion with two described histologic subytpes, although this has recently been questioned; simple type and WHO type

odontogenic fibroma

55

F>M, avg. age 40; maxilla, anterior to the first molar; expansion, loosening of teeth; unilocular to multilocular radiolucency; root resorption or divergence

odontogenic fibroma

56

_ type of odontogenic fibroma: background of fine collagen fibrils with stellate fibroblasts; may see small foci of odontogenic epithelium

simple

57

_ type of odontogenic fibroma: more cellular fibrous connective tissue; strands and nests of odontogenic epithelium

WHO

58

soft tissue counterpart to the odontogenic fibroma; most similar to the WHO type

peripheral odontogenic fibroma

59

slow growing gingival mass; may cause tooth displacement; radiograph may show areas of calcification within the soft tissue mass

peripheral odontogenic fibroma

60

considered to be of odontogenic origin, resembling the odontogenic ectomesenchyme; histologically resembles the mesenchymal portion of a developing tooth

myxoma

61

M=F, age 25-30; mandible>maxilla; asymptomatic expansion; "soap bubble" radiolucency

myxoma