Musculoskeletal Flashcards Preview

Dental Pathology > Musculoskeletal > Flashcards

Flashcards in Musculoskeletal Deck (71)
Loading flashcards...
1

hereditary disorder of bone growth; mutation of FGFR3; impaired maturation of cartilage that affects all bones; major cause of dwarfism

achondroplasia

2

short stature; shortened proximal extremities; bowed legs; normal torso length; large head to body size; lordotic posture (excessive inward curvature of lumbar vertebrae)

achondroplasia

3

heterogeneous group of heritable connective tissue disorders; mutations in either the COL1A1 or COL1A2 genes, which guide type 1 collagen formation

osteogenesis imperfecta

4

most common and least severe form of osteogenesis imperfecta; opalescent teeth

type 1

5

most severe form of osteogenesis imperfecta

type 2

6

most severe form beyond perinatal period of osteogenesis imperfecta

type 3

7

form of osteogenesis imperfecta where blue sclera fade with age

type 4

8

cortical bone appears attenuated; reduced bone matrix production; bone architecture remains immature throughout life, with woven bone failing to transform to lamellar bone

osteogenesis imperfecta

9

treatment for osteogenesis imperfecta

bisphosphonate therapy

10

hereditary disorder characterized by increased bone density; secondary to defect in osteoclastic function; thickening of cortical bone and sclerosis of cancellous bone

osteopetrosis

11

which form of osteopetrosis?: normocytic anemia; symptoms secondary to cranial nerve pressure; pathologic fracture; skull deformities, hypertelorism; delayed tooth eruption; autosomal recessive

infantile (malignant) form

12

which form of osteopetrosis?: milder, typically detected upon routine radiograph; no anemia; no cranial nerve compression; uncommon pathologic fracture; osteomyelitis; autosomal dominant

adult (benign)

13

numerous osteoclasts; lack of Howship's lacunae; dense bone formation

osteopetrosis

14

porous bones, reduced bone mass resulting in increased bone fragility; can by primary or secondary to a variety of conditions; most common: senile, post-menopausal

osteoporosis

15

which demographic is most prone to osteoporosis?

caucasian females

16

fractures of vertebrae, pelvis, femur; kyphosis (overcurvature of thoracic vertebrae, hunchback)

osteoporosis

17

disease of bone characterized by abnormal resorption and deposition of bone; unknown etiology; possible viral etiology; recent gene mutations have been identified

pagets disease of bone

18

older individuals; monostotic or polyostotic; thickened, enlarged, and weakened bones; often painful

pagets disease

19

maxilla>mandible; enlarged alveolar ridges; may see spacing of the teeth

pagets disease

20

early - decreased radiodensity and altered trabeculation; later - patchy, sclerotic bone (cotton wool); hypercementosis

pagets disease

21

increased serum alkaline phosphatase; normal calcium and phosphorous levels; elevated urinary hydroxyproline

pagets disease

22

osteoblastic formation and osteoclastic resorption of bone; basophilic reversal lines (mosaic or jigsaw pattern)

pagets disease

23

... develops in about 1% of pagets disease patients

osteosarcoma

24

defective mineralization of bone matrix; due to vitamin D deficiency

rickets and osteomalacia

25

in infancy/childhood; bowing of legs; Rachitic rosary (prominence of the costochondral junction)

rickets

26

in adults; diffuse skeletal pain; susceptibility to bone fracture

osteomalacia

27

one of the most common pathologies affect bone; causes- traumatic, stress (repetitive loading), pathologic (in an area of existing bone disease)

fractures

28

a bony ... bridges the fracture

callus

29

inflammation of the bone and marrow; implies infection (most often bacterial); entry of microorganisms (hematogenous spread, extension from a contiguous site, compound fracture)

osteomyelitis

30

can be acute or chronic; sequestrum (a detached, necrotic bone fragment) formation

osteomyelitis