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Flashcards in Hematologic Deck (59)
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1

proliferation of normal lymphoid tissue in response to antigenic challenge; clinical- lymph node enlargement; may involve nodes (commonly the anterior cervical chain), Waldeyer's ring

lymphoid hyperplasia

2

bleeding disorder secondary to a genetic deficiency of clotting factors

hemophilia

3

Hemophilia _: deficiency of factor VIII

A

4

Hemophilia _: deficiency of factor IX

B (Christmas disease)

5

deficiency of von Willibrand's factor

von Willbrand's disease

6

x-linked; severity depends upon the extent of the deficiency; increased PTT

hemophilia A

7

pseudotumor of _; hemarthrosis; increased bleeding from many dental procedures

hemophilia

8

general term, indicating a decrease in red blood cell volume (hematocrit) or concentration of hemoglobin; usually an indication of underlying systemic disease; conditions include vitamin deficiencies, liver disease, malignancies (myelophthisic _)

anemia

9

fatigue, headache, lightheadednes; may see pallor of the mucous membranes

anemia

10

genetic disorder of hemoglobin synthesis; thymine is substituted for adenine; deoxygenated hemoglobin subject to molecular aggregation and polymerization

Sickle cell anemia

11

Codominant gene; abnormal gene confers a resistance to malaria; frequently affects patients in Africa, Mediterranean basin, and Asia; 8% African Americans carry the trait

Sickle cell anemia

12

reduced blood flow to organs and tissues; susceptibility to infections secondary to spleen destruction; reduced trabeculae pattern; "hair on end" skull radiograph

Sickle cell

13

Inherited disorder of hemoglobin synthesis; similar to sickle cell anemia, carriers of the trait are resistant to the malarial organism; Mediterranean, African, Indian and Southwest Asians are more often affected; Hair on end radiograph; bone marrow hyperplasia

Thalassemia

14

hepatosplenomegaly, lymphadenopathy; tissue hypoxia; bacterial infections; high-output cardiac failure

thalassemia

15

Complete failure of hematopoietic precursor (stem) cells to differentiate into all elements of the circulation; most cases appear to be an immune-mediated disease caused by cytotoxic T lymphocytes; unknown etiology, but environmental toxins, viruses, and drugs have been impicated

aplastic anemia

16

fatigue, lightheadedness (secondary to erythrocyte deficiency); bleeding disorders (secondary to thombocytopenia)

aplastic anemia

17

Infections (secondary to leukocytic deficiency); Oral: -hemorrhage, petechiae, pallor, ulcerations, gingival hyperplasia

aplastic anemia

18

Aplastic anemia: recurrence is common and patient are at increased risk of developing _ _

acute leukemia

19

Decreased numbers of circulating neutrophils; genetic (infants) or acquired (older children and adults), secondary to numerous infectious, neoplasia, or chemotherapeutic agents

neutropenia

20

increased susceptibility to bacterial infections (ear, oral cavity, later pulmonary); oral lesions: gingival ulcerations

neutropenia

21

decrease or absence of cells of granulocytic derivation, particularly neutrophils; decreased production or increased destruction secondary to certain drugs or some syndromes; may be idiopathic

agranulocytosis

22

bacterial infections and their associated symptoms; oral lesions: punched-out ulcerations, NUG

agranulocytosis

23

idiopathic, periodic reductions in neutrophils; isolated or autosomal dominant; symptoms are associated with the neutrophil count

cyclic neutropenia

24

childhood onset; low neutrophil counts (3-6 days) correspond to infections and their associated symptoms; cycles are approximately 21 days; oral and other GI ulcerations; periodontal bone loss and gingival recession; "floating in air" radiographic appearance

cyclic neutropenia

25

decrease in the number of platelets; secondary to reduced production, increased destruction or sequestration in the spleen (during splenomegaly); systemic diseases such as lupus or HIV also may be characterized by thrombocytopenia

thrombocytopenia

26

_ thrombocytopenic purpura- occurs in childhood after nonspecific viral infection

idiopathic

27

_ thrombocytopenic purpura- coagulation disorder, resulting in numerous thrombi within small blood vessels

thrombotic

28

submucosal/cutaneous hemorrhage; epistaxis; hemoptysis; GI or urinary bleeding; petechia, ecchymosis, hematoma; spontaneous gingival hemorrhage

thrombocytopenia

29

thrombocytopenia: biopsy specimens will show _ deposition within blood vessels

fibrin

30

idiopathic increase in red blood cell mass, usually concurrently with uncontrolled platelet and granulocyte production; probably secondary to the behavior of an abnormal progenitor stem cell

polycythemia vera