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Flashcards in Skin Diseases Deck (68):
1

heterogenous group of disorder with different prognoses; characterized by blisters, ulcer, or erosions of skin, mucosa, or both; many with immunological etiology

vesiculobullous diseases

2

superficial skin infection (s. pyogenes and s. aureus); most common in children with poor hygeine, crowded living conditions and hot and humid climates

impetigo

3

arises in areas of trauma; multiple vesicles that rupture, leaving a honey-colored crust

impetigo

4

common chronic mucocutaneous disease; probably immune-mediated; may have only skin, only oral, or both; skin lesions- purple, polygonal, pruritic papules

lichen planus

5

reticular or erosive oral lesions; reticular-interlacing white lines, buccal mucosa; erosive-ulcers with erythema and white streaks

lichen planus

6

hyperkeratosis; degeneration of basal cell layer; "saw-toothed" rete ridges

lichen planus

7

"band-like" infiltrate of lymphocytes

lichen planus

8

shaggy band of fibrinogen at basement membrane zone seen with direct immunofluorescence

lichen planus

9

drug of choice for lichen planus

betamethasone gel

10

chronic skin disease characterized by an increase in the proliferative activity of keratinocytes; both genetic and environmental factors

psoriasis

11

2nd decade, waxing and waning course with lesions improving during the summer; scalp, elbows, knees

psoriasis

12

erythematous plaques with silvery scales

psoriasis

13

marked hyperparakeratosis; elongated rete ridges; perivascular inflammation; munro abscesses

psoriasis

14

PUVA (treatment for psoriasis) stands for

psoralen and ultraviolet A

15

hetergeneous group of inherited blistering mucocutaneous disorders; autosomal dominant or recessive; 3 broad categories: Simplex, Junctional, Dystrophic

epidermolysis bullosa

16

which form of epidermolyis bullosa?: vesicles/bullae that become ulcers and erosions that heal with scarring; gingival erythema, recession and reduction in vestibular depth

dominant dystrophic

17

which form of epidermolysis bullosa?: much more serious; secondary infection; mitten deformity; microstomia

recessive dystrophic

18

Intraepithelial clefting

epidermolysis bullosa (simplex)

19

subepithelial clefting (lamina lucida or lamina densa)

epidermolysis bullosa (junctional and dystrophic)

20

increased incidence of cutaneous squamous cell carcinoma

epidermolysis bullosa

21

acute, self-limiting ulcerative disorder, probably immune-mediate; 50%-unknown, 25%-drugs, 25%-herpes

erythema multiforme

22

EM- skin or mucosa only

erythema multiforme minor

23

EM (Stevens-Johnson syndrome)- at least two mucosal sites plus skin involvement

erythema multiforme major

24

EM- Lyell's disease

toxic epidermal necrolysis

25

young adults; may experience prodrome; hemorrhagic crusting of lips; widespread oral ulcers with ragged margins; labial, buccal mucosa and tongue; "target" lesions of skin

EM

26

diffuse sloughing of the skin and mucosa; older patients

toxic epidermal necrolysis

27

destruction of keratinocytes; subepithelial edema; mixed inflammatory infiltrate; perivascular inflammation

EM

28

benign lesion associated with HPV types 2,4 and 40; relatively contagious, with potential for autoinoculation

verruca vulgaris (common wart)

29

most commonly in children; skin of hands; more commonly sessile; variable color, but typically white

verruca vulgaris

30

papillary, hyperkeratotic proliferation of epithelium; rete ridges appear to converge toward the center of the lesion; course keratohyaline granules

verruca vulgaris

31

koilocytosis

verruca vulgaris

32

controversial lesion of unknown etiology; UV exposure may play a role in its pathogenesis; self-limiting lesion with clinical and histopathologic resemblance to well-differentiated squamous cell carcinoma

keratoacanthoma

33

predominantly a lesion of skin; sessile, dome shaped lesion with central keratin plug

keratoacanthoma

34

commonly involves the vermilion border of the upper of lower lip; rapid enlargement allows for clinical differentiation from squamous cell carcinoma

keratoacanthoma

35

proliferation of squamous epithelium that may be difficult to distinguish from squamous cell carcinoma; dyskeratosis, keratin pearl formation

keratoacanthoma

36

central keratin-filled; adjacent epithelium appears normal; acute angle is formed between the adjacent epithelium and the lesion

keratoacanthoma

37

lesions will usually regress spontaneously in 6-12 months, but leave an unaesthetic depressed scar

keratoacanthoma

38

common lesion of the elderly; unknown etiology, but correlated with sun exposure; may be hereditary

seborrheic keratosis

39

exclusively a skin lesion; face, trunk, extremities; tan to brown roughened plaques; "stuck on" apperance

seborrheic keratosis

40

exophytic, papillary proliferation of basaloid cells; horn cysts and pseudo-horn cysts; 3 main types

seborrheic keratosis

41

multiple seborrheic keratoses may be an indicator of internal malignancy

Leser-Trelat sign

42

benign proliferation of nevus cells, which are derived from neural crest and are related to melanocytes; acquired or congenital; intraoral lesions are uncommon

acquired melanocytic nevus (mole)

43

3 stages of acquired melanocytic nevus

junctional; compound; intradermal

44

proliferation of nevus cells that vary in morphology depending upon their depth; superficially arranged in theques

acquired melanocytic nevus

45

proliferation of melanocytes within the subepithelial connective tissue; 2nd most common intraoral; tyndall effect

blue nevus

46

dendritic melanocytes in the connective tissue; usually arranged parallel to the surface

blue nevus

47

common premalignant lesion of skin; secondary to cumulative sun exposure (UV radiation)

actinic keratosis (solar keratosis)

48

face, dorsum of hands, scalp; irregular scaly plaques of variable color; rough "sandpaper" feel

actinic keratosis

49

hyperkeratosis and acanthosis; some degree of epithelial dysplasia; basophilic degeneration of underlying connective tissue

actinic keratosis

50

malignant neoplasm of melanocytes; may arise from preexisting benign melanocytic lesions or from skin subject to a history of acute solar damage; 3rd mors common cancer but #1 cause of death among skin cancers

melanoma

51

4 main types: lentigo maligna, superficial spreading(most common), nodular, acral lentiginous(most oral)

melanoma

52

A of ABCDs

asymmetry

53

B of ABCDs

irregular borders

54

C of ABCDs

color variegation

55

D of ABCDs

diameter greater than 6 mm

56

s of ABCDs

symptoms

57

atypical melanocytes along the basal epithelial layer (lateral growth phase); vertical growth begins as these celles invade the connective tissue

melanoma

58

melanocytic distribution throughout the epithelium seen in melanoma

pagetoid spread

59

extremely common low-grade cutaneous malignancy secondary to chronic sun exposure; tumor cells arise from the basal cell layer of skin and appendages

basal cell carcinoma

60

most common location is the middle of the face; associated with nevoid basal cell carcinoma syndrome

basal cell carcinoma

61

several forms, with noduloulcerative being the most common

basal cell carcinoma

62

basaloid cells in islands, strands and nests that arise from the basal layer of the epithelium and penetrate the underlying connective tissue

basal cell carcinoma

63

distinct peripheral palisading and stromal retraction

basal cell carcinoma

64

2nd most common of skin cancers; similar risk factors as basal cell carcinoma

squamous cell carcinoma

65

autosomal dominant genodermatosis characterized by a lack of cohesion among the surface epithelial cells; mutation affects the integrity of the desmosomal complex

darier's disease (keratosis follicularis)

66

erythematous, pruritic papules of the skin; pits and keratoses of the palms and soles; nails that feature longitudinal lines, ridges, or splits

darier's disease

67

multiple normal to white flat-topped papules; frequently seen on the palate or alveolar mucosa

darier's disease

68

suprabasilar acantholysis; "test tube" rete ridges; central keratin plug; corps ronds and grains

darier's disease