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HBB Flashcards

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1
Q

Haemophilus Features

A

Non motile
Non sporing
Gram -ve
Oxidase +ve

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2
Q

Oxidase Positive Organisms

A

PVNCH
Pseudomonas
Vibrio
Neisseria
Campylobacter
HBB (Hemophilus, Bordetella and Brucella)

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3
Q

H. Influenzae also known as

A

Pfeiffer’s bacillus

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4
Q

H. Influenzae requires which factors

A

X and V

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5
Q

Virulence factors of H influenzae

A

Capsular polysaccharide - 6 types (A to F)
H1b - Most virulent (used for H1b PRP vaccine)

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6
Q

H. Influenzae diseases ranges in humans from

A

Invasive and
Non invasive

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7
Q

Capsule in case of Invasive and Non invasive H. Influenzae

A

Invasive - encapsulated
Non Invasive - Non encapsulated

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8
Q

Disease spread in Invasive and Non invasive H influenzae

A

Invasive - Blood
Non invasive - locally

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9
Q

H1b seen in which form of H influenzae

A

Invasive

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10
Q

Blood culture will be positive in which form of H influenzae

A

Invasive

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11
Q

Infections caused by invasive form of H influenzae

A

Meningitis
Sepsis
Pneumonia

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12
Q

Infections caused by Non invasive form of H influenzae

A

Otitis media
Sinusitis
Exacerbation of COPD

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13
Q

Clinical features related to H influenzae

A

Meningitis
Croup (Laryngotracheobronchitis)
Pneumonia
Suppurative lesions

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14
Q

Microscopic Findings in Case of H influenzae

A

Gram negative Coccobacilli

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15
Q

Culture findings in case of H influenzae

A

X factor (hemin)
V factor (NAD Or NADP)

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16
Q

Satellitism shown on blood agar by which organism

A

H. Influenzae

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17
Q

Treatment of H influenzae

A

Cefotaxime or Ceftriaxone

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18
Q

Precaution or vaccine for H influenzae

A

H1b PRP Vaccine

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19
Q

H. Aegypticus is also known as

A

Koch weaks bacillus

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20
Q

H Aegypticus causes

A

Pink eyes
Brazilian purpeuric fever (Conjunctivitis leading to septicemia)

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21
Q

H Ducreyi causes

A

Chancroid - Painful soft Genital ulcers

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22
Q

Culture media for H Ducreyi

A

Grows on chocolate agar supplemented with Isovitalex or fetal calf serum

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23
Q

Staining and tissue biopsy finding for H Ducreyi

A

Bipolar staining (Safety pin appearance)
Tram track/School of fish appearance

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24
Q

Treatment of H. Ducreyi infection

A

Azithromycin

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25
Organisms containing Only Factor X
Dus - H. Ducreyi
26
Organism containing only Factor V
Paanch - Para H. Parainfluenza H. Parahemolyticus H. Paraphrophilus
27
Organisms containing both Factor X and V
BHAI B - Both H - H. Hemolyticus A - H. Aegypticus I - H. Influenzae
28
Normal mouth Commensals or HACEK organisms
H - Haemophilus A - Aggregatibacter C - Cardiobacterium E - Eikenella K - Kingella
29
HACEK are known to cause
Endocarditis Respiratory infections UTI
30
Bordetella features
Non motile Non sporing Capsule +
31
Bordetella pertussis causes
Pertussis/Whooping cough/100 day cough
32
Virulence factors of Bordetella pertussis
Agglutinogens - helps in attachment Filamentous hemagglutinin (FHA) Pertactin - outer membrane protein
33
Filamentous hemagglutinin (FHA) Is used for
Used in Acellular pertussis vaccine
34
Toxin responsible for Bordetella pertussis infection
Pertussis toxin
35
Pertussis toxin exhibits
LPF (Lymphocytosis producing factor) HCF (Histamine secretizing Factor) IAP (Islet activating protein) - Hypoglycemia
36
Pertussis MOA
Increases adenylate cyclase (cAMP)
37
Incubation period of Bordetella pertussis
1-2 weeks
38
Phases of Bordetella pertussis infection
Catarrhal - low grade fever, Dry cough, Max infectivity Paroxysmal - Bouts of cough, inrush of air into lungs (whoop) Convalescent - lesser severity
39
Swabs are transported in which media in case of Bordetella pertussis
Casamino acid solution/Stuart media
40
Specimen taken for Bordetella infection
Nasal swab, Per nasal, Per oral 6 swabs takes Dacron or Calcium alginate swabs are used ( not cotton)
41
Culture media used for diagnosis of Bordetella pertussis
Bordet gengou medium - Shows Mercury drop/Bissected pearls appearance
42
Bordetella pertussis Mnemonic
Bord - Body (capsule) Bordet Gengou medium B and P - Bissected pearls
43
Treatment of Bordetella pertussis infection
Erythromycin, Azithromycin
44
Prevention of Bordetella pertussis infection
1) Whole cellular vaccine (FHA, Pertactin, Agglutinogens, Pertussis toxin) - No complications 2) Whole cell killed vaccine
45
Complication of whole cell killed vaccine give for Pertussis
Post vaccinal encephalopathy
46
Classification of Brucella
NOMEN System MASC-ON M - Melitensis A - Abortus S - Shis C - Canis O - Ovis N - Neutamae
47
Brucella Melitensis
Sheep/goat Most pathogenic M antigen
48
Antigen seen in Brucella Abortus
A Antigen
49
Virulence factors of Brucella
LPS BvrR/BurS - binding
50
Transmission of Brucella infection
Zoonotic disease M/c direct contact > raw milk
51
Clinical features of Brucella infection
Goes to reticuloendothelial cells Night sweats Hepatosplenomegaly Arthritis
52
Incubation period of Brucella
10-30 days
53
Types of infection caused by Brucella
1)Latent - no clinical evidence, Serology +ve 2)Acute/Subacute - Fever, Arthralgia, Nocturnal sweating, Low platelet count (Bleeding) 3)Chronic - low grade
54
Medium used for diagnosis of Brucella
Castaneda medium (biphasic) -;Solid and liquid
55
Brucella is Catalase, Oxidase and Urease
Positive
56
Which agglutination test is shown by Brucella
Standard agglutination test
57
Test done on animals in case of Brucella
Milk ring test - blue or purple ring at top Bengal card test Whey agglutination test
58
Treatment of Brucella infection
Doxycycline × 45 days + Streptomycin im daily for 14 days
59
Treatment recommended by WHO for Brucella
Doxycycline + Rifampicin for 6 weeks
60
Treatment for Neurobrucellosis
Doxycycline + Rifampicin + Ceftriaxone

Microbiology (37 decks)

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