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Microbiology > Ricketssia And Miscallaneous Bacteria > Flashcards

Ricketssia And Miscallaneous Bacteria Flashcards

(64 cards)

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1
Q

Ricketssiae features

A

Obligate intracellular organism
Cannot grow on artificial media
Grow in cell lines only

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2
Q

Ricketssiae infection is transmitted by

A

Arthropod borne transmission except Coxiella (inhalational)

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3
Q

Rash can be seen in all Ricketssial infections except

A

Coxiella

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4
Q

Pathogenesis of Ricketssial infections

A

Reservoir host - vector - humans - multiply locally and enter blood stream - localise at endothelium - degenerate and thrombosis - Occlusion

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5
Q

Epidemic typhus cause and transmitted by

A

R. Prowazekii
Louse

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6
Q

Endemic typhus cause and transmitted by

A

R. Typhi
Flea

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7
Q

Rocky mountain spotted fever cause and vector

A

R. Ricketsii
Tick

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8
Q

Cause of African tick typhus and vector

A

R. Conori
Tick

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9
Q

Cause of Ricketssial pox and vector

A

R. Akari
Mite

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10
Q

Scrub typhus is caused by and Vector

A

Orientia tsutsugamushi
Mite

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11
Q

Mnemonic of Ricketssial infections

A

LET - Louse epidemic typhus
FEN - Flea Endemic typhus
TRIA - Tick RMSF Indian tick and African tick typhus
PSM - Ricketssial pox, Scrub typhus, Mite

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12
Q

Louse features in case of Epidemic typhus

A

On fever, louse leaves body (sensitive to heat)
Not a zoonotic disease
Infection is transmitted by entry of Louse feces into body via abrasions

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13
Q

Incubation period of Epidemic typhus/Jail fever

A

5-15 days

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14
Q

Clinical features of Epidemic typhus

A

Fever , Chills
After 4-5 days, Rash first appear on trunk and then limbs - Delirious - fatal

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15
Q

All Ricketssial infections causes rash first on trunk and then limbs except

A

Rocky Mountain spot fever - starts from extremities then goes to trunk

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16
Q

Brill zinser disease is due to

A

Reactivation of Epidemic typhus
Less severe
No vector

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17
Q

Neil mooser reaction/Tunica reaction is shown by

A

R. Prowazekii - negative Reaction
R. Typhii (Endemic typhus) - Positive reaction

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18
Q

Procedure of Neil mooser reaction/Tunica reaction

A

Intraperitoneal inoculation of guinea pig with blood from case - Scrotal inflammation - +ve Reaction

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19
Q

Scrub typhus is also known as

A

Chigger borne disease

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20
Q

Zoonotic tetrad of Scrub typhus

A

Chiggers larvae - transported by trombiculid mites, Carry infection in Rats/Squirrel, Infect humans, Present in vegetation/Shrubs

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21
Q

Pathogenesis of Scrub typhus

A

Mite larvae/Chiggers - Seek moist areas of body (Axilla, groin) - After 1-3 weeks Eschars at site of bite along with Fever , Nausea, vomiting, Lymphadenopathy

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22
Q

Complications of Scrub typhus

A

Pneumonia, ARDS, Shock

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23
Q

Special stains used for diagnosis of Ricketssial organisms

A

Giemsa
Castaneda
Gimenez
Macchiavello

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24
Q

Culture used in Ricketssial infections

A

Yolk sac of embryonated hen’s egg
Cell lines (Vero, Hela, Hep2, Detroit 6)

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25
Serological test done for diagnosis of Ricketssial infections
Weil Felix reaction IgM (ELISA)
26
Weils Felix reaction findings
Scrub typhus - OXK +ve Others - OX19 and OX 2 +ve Brill zinser - not shows any positivity
27
False Positive Weil Felix reaction can be seen in
Proteus infection
28
Gold standard serological test for Ricketssial infections
Indirect fluorescence antibody test
29
Treatment of Ricketssial infections
Doxycycline or Tetracycline
30
Genius Coxiella is part of which family
Rickettsiae
31
Features of Coxiella brunetti
Intracellular parasite Has no vector No weil Felix reaction No rash
32
Transmission methods of Coxiella brunetti
Inoculation - Vets Inhalational - dried feces Ingestion - Meat,Milk
33
Coxiella brunetti causes
Q fever Intestinal Pneumonia Chronic hepatitis, Endocarditis
34
Histopathology finding in Q fever
Doughnut granuloma or Fibrin ring Granuloma
35
Stain used for diagnosis of Coxiella brunetti
Giemsa Gimenez Castaneda Macchiavello
36
Treatment of Coxiella brunetti infection
Tetracycline
37
Vaccine available for Q fever
Q vax - In Australia - for more than 15 yrs of age
38
All Ricketssiae are Obligate intracellular except
Bartonella
39
Bartonella includes
Bartonella Bacilliformis Bartonella Quintana Bartonella Henselae
40
Bartonella Bacilliformis is also known as and transmitted by
AKA Oroya fever and transmitted by Sand fly
41
Clinical features of Bartonella Bacilliformis infection
Fever Hemolytic anemia
42
Bartonella Henselae causes
Cat scratch disease Bacillary angiomatosis Bacillary peliosis (Liver, spleen)
43
Stellate granulomas is seen in
Cat scratch disease caused by Bartonella Henselae
44
Stain used for diagnosis of Bartonella Henselae infection
Warthin and silver starry stain
45
Bartonella Quintana causes
Five day fever/Trech fever No animal reservoir Only in humans
46
Bartonella Quintana infection is transmitted by
Body louse
47
Chlamydia features
3ABC Atypical bacteria Do not grown on Artificial media (Obligate intracellular) ATP From host (ATP Parasite) Basophilic bacterial inclusions Cannot be Cultured No peptidoglycan cell wall
48
Types of Chlamydia
Chlamydia - Chlamydia trachomatis Chlamyodophila - Chlamydophila pneumoniae, Chlamydophila psittace
49
FORMS Or BODY of Chlamydia
Elementary body Reticulate body
50
Features of Elementary body
EEEII Elementary Extracellular Equal - RNA = DNA I - Metabolically inactive I - Infectious form Small
51
Reticulate body of Chlamydia features
Intracellular RNA > DNA Metabolically active Large Replicating form
52
Serotype A, B, Ba, C of C. Trachomatis and causes
A,B,Ba,C - causes Trachoma
53
Serotype of C. Trachomatis and causes
A,B,Ba,C - causes Trachoma
54
Most common infectious cause of Blindness in India is
Trachoma caused by Chlamydia trachomatis - M/C Type B
55
D,E,F,G,H,I,K Serotypes of Chlamydia trachomatis causes
Non gonococcal urethritis - discharge Opthalmia neonatarum Inclusion conjunctivitis (not cause blindness) Infant pneumonia
56
L1,L2,L3 serotypes of Chlamydia are known to cause
Lymphogranuloma venereum - M/C - L2
57
Clinical features of Lymphogranuloma venereum
ABCDEFG A - Asymptomatic B - Bubos (Painful LN) - Inflamed inguinal LN - Groove sign C - C. Trachomatis L1,L2,L3 D - Doxycycline (DOC) E - Esthionine (Rectal and vulval stricture) F - Freisz test (skin test), Fitz hugh Curtis Syndrome (Perihepatitis) G - Groove sign
58
Strains of C. Pneumoniae and C. Psittaci
C. Pneumoniae - one strain (Twar) C. Psittaci - many strains
59
Stains used for Diagnosis of C. Trachomatis infection
Gram poor Giemsa Grimenez Castenada Macchiavello
60
Cells lines methods used for diagnosis of C. Trachomatis
Hela Hep2 McCoy
61
Most sensitive and specific test for diagnosis of C. Trachomatis
PCR/NAAT
62
Chlamydia pneumoniae causes
Taiwan acute respiratory strain - 3rd most common cause of CAP
63
Chlamydia pneumoniae is associated with
Atherosclerosis Asthma Sarcoidosis
64
C. Psittaci causes and transmission
Causes pneumonia Transmitted from birds(Parrots) to human

Microbiology (37 decks)

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