Heme/Onc - First Aid Flashcards Preview

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Flashcards in Heme/Onc - First Aid Deck (309)
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1

Erythrocyte Features

-carries O2 to tissues and CO2 to lungs -anucleate, biconcave -large surface area to volume ratio for rapid gas exchange -life span = 120 days -uses glucose for energy

2

The membrane of erythrocytes contains...

chloride-HCO3- antiporter which allows RBCs to export HCO3- and transport CO2 from the periphery to the lungs for excretion.

3

A reticulocyte is...

an immature erythrocyte; a marker of erythroid proliferation.

4

Anisocytosis

varying size

5

Poikilocytosis

varying shape

6

Platelet (thrombocyte) features

-invovled in primary hemostasis -small cytoplasmic fragment derived from megakaryocytes -life span = 8-10 days

7

When a platelet is activated by endothelial injury, it will...

aggregate with other platelets and interact with fibrinogen to form a platelet plug.

8

Platelets contain...

dens granules (ADP and calcium) and alpha granules (vWF and fibrinogen).

9

Thrombocytopenia or decreased platelet function results in...

petechiae.

10

vWF receptor

GPIb

11

Fibrinogen receptor

GPIIb/IIIa

12

Leukocytes are divided into...

granulocytes (neutrophils, eosinophils, basophils) and mononuclear cells (monocytes and lymphocytes).

13

Normal Leukocyte level

4000-10000

14

WBC differential from highest to lowest

Neutrophils Like Making Everything Better Neutrophils (54-62%) Lymphocytes (25-33%) Monocytes (3-7%) Eosinophils (1-3%) Basophils (0-.75%)

15

Neutrophils are...

an acute inflammatory response cell seen in bacterial infections. -phagocytic -multilobed

16

Small neutrophils with more numerous specific granules contain...

ALP, collagenase, lysozyme and lactoferrin.

17

Larger neutrophils with less numerous azurophilic granules contain...

proteinases, acid phophatase, myeloperoxidase and beta-glucoronidase.

18

Hypersegmented PMNs (5 or more lobes) are seen in...

vitamin B12/folate deficiency.

19

Increased band cells (immature neutrophils) reflect states of...

myeloid proliferation (bacterial infections, CML).

20

Monocytes differentiate into...

macrophages in tissues.

21

Monocyte features

-large, kidney-shpaed nucleus -"frosted glass" cytoplasm

22

Macrophages act to...

phagocytose bacteria, cellular debris and senescent RBCs and scavenge damaged cells and tissue.

23

Macrophages are activated from monocytes via...

gamma-interferon.

24

Macrophages can function as...

antigen presenting cells via MHC II.

25

Surface marker for macrophages

CD14

26

Macrophages are an important component of...

granuloma formation.

27

Eosinophils defend against...

helminthic infections (w/ major basic protein).

28

Eosinophils features

-bilobate nucleus -packed with large eosinophilic granules -highly phagocytic for Ag-Ab complexes

29

Eosinophils produce..

histaminase and arylsulfatase (these help limit rxn following mast cell degranulation).

30

Causes of eosinophilia

NAACP N: neoplasia A: asthma A: allergies C: CT disorders P: parasites