Flashcards in Immunology - First Aid Deck (339)
LN Follicle is the site of...
B-cell localization and proliferation.
In the outer cortex, primary follicles are...
dense and dormant.
Secondary follicles have...
pale central germinal centers.
The LN medulla consists of...
medullary cords (closely packed lymphocytes and plasma cells and medullary sinuses).
Medullary sinuses communicate with...
efferent lympmhatics and contain reticular cells and macrophages.
The LN paracortex houses...
T cells. It is the region of the cortex between the follicles and medulla.
The paracortex contains high endothelial venules through which...
T and B cells enter from the blood.
The paracortex is not well developed in...
pts with DiGeorge syndrome.
The paracortex enlarges in...
an extreme cellular immune response (ex. viral infection).
Cervical LNs drain...
the head and neck.
Hilar LNs drain...
Mediastinal LNs drain...
the trachea and esophagus.
Axillary LNs drain...
the upper limb, breast, and skin above the umbilicus.
Celiac LNs drain...
the liver, stomach, spleen, pancreas and upper duodenum.
Superior mesenteric LNs drain...
the lower duodenum, jejunum, ileum, and colon to the splenic flexure.
Inferior mesenteric LNs drain...
the colon from the splenic flexure to the upper rectum.
Internal iliac LNs drain...
the lower rectum to teh anal canal (above pectinate), bladder, vagina and prostate.
The para-aortic LNs drain...
testes, ovaries, kidneys and uterus.
The superficial inguinal LNs drain...
the anal canal (below pectinate), and skin below the umbilicus (except popliteal).
The popliteal LNs drain...
the dorsolateral foot and posterior calf.
The right lymphatic duct drains...
the right side of the body above the diaphragm.
The thoracic duct drains...
everything else into the junction of the left subclavian and internal jugular veins.
The sinusoids of the spleen are...
long, vascular channels in the red pulp with fenestrated "barrel hoop" basement membrane.
In the spleen, T cells are found in...
the periarterial lymphatic sheath within the white pulp.
In the spleen, B cells are found in...
follicles within the white pulp.
The marginal zone of the spleen is in between the...
red pulp and white pulp, contains APCs and specialized B cells, and is where APCs present blood-borne antigens.
Macrophages in the spleen act to...
remove encapsulated bacteria.
Splenic dysfunction (postsplenectomy, sickle cell) leads to...
decreased IgM which leads to decreased complement activation, which leads to decreased C3b opsonization which leads to increased susceptiblity to encapsulated organisms.
1. Strep pneumo
2. H. influenzae
3. N. meningitidis
4. E. coli
7. group B Strep