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Flashcards in Psych Drugs Deck (62)
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1

CNS Stimulants (4)

1. methylphenidate 2. dextroamphetamine 3. methamphetamine 4. phentermine

2

Mechanism of CNS Stimulants

-increase catecholamines at the synaptic cleft, esp. NE and DA.

3

Clincial use of CNS stimulants

ADHD Narcolepsy Appetite control

4

Antipsychotics (neuroleptics) (5)

1. Haloperidol 2. Trifluoperazine 3. Fluphenazine 4. Thioridazine 5. Chlorpromazine

5

Mechanism of Antipsychotics

All typical antipsychotics block dopamine D2 receptors (increase cAMP).

6

Clinical use of antipsychotics

-schizophrenia (mainly + symptoms) -psychosis -acute mania -Tourette's

7

Antipsychotics are very slow to be removed from the body because...

they are highly lipid soluble and are stored in body fat.

8

Toxicity of antipsychotics

-extrapyramidal system effects (dyskinesias) -endocrine side effects (galactorrhea) -dry mouth, constipation (from blocking muscarinic receptors) -hypotension (from blocking alpha-1 receptors -sedation (from blocking histamine receptors)

9

Neuroleptic malignant syndrome

toxicity of antipsychotics causing rigidity, myoglobinuria, autonomic instability and hyperpyrexia

10

Treatment forNeuroleptic malignant syndrome

-dantrolene -D2 agnoists (bromocriptine)

11

Tardive dyskinesia

toxicity of antipsychotics casuing oral-facial movements

12

High potency antipsychotics

-Trifluoperazine, Fluphenazine, Haloperidol *these cause neurologic side effects (EPS system)

13

Low potency antipsychotics

-Chlorpromazine, Thioridazine *these cause non-neurologic side effects

14

Chlorpromazine can also cause...

cornela deposits.

15

Thioridazine can cause...

retinal deposits.

16

Haloperidol can also cause...

NMS or tardive dyskinesia.

17

Evolution of EPS side effects

-4 hr acute dystonia -4 day akathisia -4 wk bradykinesia -4 month tardive dyskinesia

18

Atypical Antipsychotics (6)

1. Olanzpaine 2. Clozapine 3. Quetiapine 4. Risperidone 5. Aripiprazole 6. Ziprasidone

19

Clinical use of atypical antipsychotics

-schizophrenia (+ and - symptoms) -Bipolar -OCD -anxiety disorder -depression -mania -tourette's

20

Olanzapine/Clozapine may cause...

significant weight gain.

21

Clozapine may cause...

agranulocytosis (requires weekly WBC monitoring) and seizure.

22

Risperidone may increase...

prolactin (lactation/gynecomastia) leading to decreased GnRH, LH and FSH (irregular menstruation/fertility).

23

Ziprasidone may...

prolong the QT interval.

24

Clinical use of Lithium

-mood stabilizer for bipolar disorder -blocks relapse and acute manic episodes -SIADH

25

Toxicity of Lithium

-tremor -sedation -edema -heart block -polyuria -teratogenesis

26

Lithium causes polyuria because...

it is an ADH antagonist causing nephrogenic DI.

27

Fetal cardiac defects from lithium include...

Ebstein anomaly and malformation of the great vessels.

28

Buspirone mechanism

stimulates 5-HT(1A) receptors

29

Use of Buspirone

-generalized anxiety disorder (1-2 wks to take effect) (does not interact with alcohol)

30

SSRIs (4)

1. Fluoxetine 2. Paroxetine 3. Sertraline 4. Citalopram