NW and OW NHP models Flashcards Preview

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Flashcards in NW and OW NHP models Deck (209)
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91

which viruses induce hepatitis in only a few OW species

B,C, delta

92

which NHP species are susceptible to both Hep A and B

marmosets and chimpanzees

93

which NHP species are most susceptible to Hep E

cynos and Aotus monkeys

94

what is the animal model for Hep A

Aotus spp, Marmosets and Tamarins

95

model of choice for Hep A research

Marmosets

96

model of choice for Hep B research

Chimpanzee

97

model of choice for Hep E research

Aotus monkey

98

closest viral relative to Hep C that can be used as a model?

GBV-B, causes acute hepatitis, increased liver enzymes that quickly return to normal as virus is cleared

99

animal model for GBV-B as model for Hep C research

Saguinus spp, Callithrix jaccus

100

animal model for Cholelithiasis

Aotus spp, Callithrix jacchus, Saimiri spp

101

characteristics of Cholelithiasis

Aotus and Callithrix, not based on cholesterol in the diet, Squirrel monkey requires addition of cholesterol to the diet. The frequency of stone formation appears to be inversely related to the concentration of cholesterol in the plasma. There is a suggestion that regimens which lower plasma cholesterol may result in accelerated gallstone formation.

102

animal model of cholesterol cholelithiasis

Aotus spp

103

characteristics of cholesterol cholelithiasis

Aotus monkeys spontaneously develop cholesterol gallstones when fed a diet supplemented with 1.5% cholesterol.

104

NHP animal model for Gilbert's syndrome

Saimiri boliviensis

105

characteristics of model for Gilbert's syndrome

nonhemolytic unconjugated hyperbilirubinemia, defect in hepatic uptake of unconjugated bilirubin and/or a conjugating enzyme deficiency, plasma of normal Bolivian squirrel monkeys what are fasted for 24hrs have a hyperbilirubinemia. most likely due to the presence of the hepatic enzyme UDP-glucuronyl transferase that results in a higher plasma and hepatic bilirubin level during a fast.

106

animal model of hemochromatosis

Callithrix jacchus

107

characteristics of model of hemochromatosis

characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissues especially liver, pancreas, and skin. will seek Kupffer cells in the liver lining sinusoids eating all the hemosiderin

108

animal model of gout

Cebus, Ateles, Lagothrix, Saguinus spp

109

characteristics of model of gout

NHP and humans lack uricase leading to hyperuricemia with subsequent deposition of urates in and about the joints.

110

animal model of Parkinson's Disease

Callithrix jacchus

Macaca mulatta

Macaca nemestrina

Chlorocebus aethiops

111

characteristics of Parkinson's model

acute exposure to MPTP causes motor symptoms/signs indistinguishable from PD. Lewy bodys are the characteristic intracellular inclusion seen in the brain. MPTP induces and acute, toxic disorder associated with injury to nigral neurons, whereas PD is a chronically progressive disorder of unknown cause. Experimental animals do not develop the cognitive and memory impairments that occur in PD

112

animal model for Cerebral Beta-Amyloid Angiopathy

Saimiri spp

113

characteristics of Cerebral Beta-Amyloid Angiopathy

manifest beta-amyloid deposition in the cerebral blood vessels with age. used to test in vivo beta-amyloid labeling strategies

114

animal model for Multiple Sclerosis/ Experimental Allergic Encephalomyelitis

Callithrix jacchus

Macaca mulatta

Macaca fascicularis

115

characteristics of Multiple Sclerosis model

called experimental allergic or autoimmune encephalomyelitis. sensitization to myelin basic protein (BP) induces a cell-mediated delyated-type hypersensitivity reaction to host myelin

116

how do you causes relapsing remitting EAE

treat acute attack with dexamethasone for 3 days

117

animal model for Spongiform Encephalopathy

Saimiri spp, Saguinus spp

118

characteristics of Spongiform encephalopathy model

mental and physical abilities deterioriate and a myrial of tiny holes appear in the cortex, causing it to appear like a sponge.

119

animal model of neurodegenerative disease

aged Saimiri spp

120

characteristics of neurodegenerative disease model

aged NHP develop age associated behavioral and brain abnormalities similar to those in aged humans such as degenerative changes, neuritis and deposits of amyloid in senile plaques and around blood vessels