NW and OW NHP models Flashcards Preview

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Flashcards in NW and OW NHP models Deck (209)
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121

animal model for Lissencephaly

Saimiri spp

122

characteristics of Lissencephaly model

Saimiri is highest species of primate with a lissencephalic brain, used to study cortical spreading depression in a highly encephalized brain

123

animal model for Viral Encephalitis and epilepsy

intracerebral injection with canine distemper virus (CDV), causes acute neurological signs of viral encephalitis such as seizures and myoclonus, lesions resemble childhood acute viral encephalitis and subacute sclerosing panencephalitis

124

animal model for Torticollis

Callithrix jacchus

125

characteristics of model for Torticollis

unilateral injection of 6-hydroxy-dopamine into the lateral hypothalamus resulted in persisting (days to weeks) severe torticollis with the head deviated toward the side of the lesion

126

animal model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

Cebus apella

127

characteristics of model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

in utero exposure to DES (diethylstilbestrol

128

animal model of Chlamydial infections

NW, OW, and great apes

129

characteristics of animal model of Chlamydial infections

Chlamydia trachomatis infection of primate genital tract, pathologic changes similar to humans. Owl monkey model for ocular trachoma

 

Trachoma is major blinding disease

130

animal model for Twinning, Chimerism, and immunologic tolerance

Callithrix and Saguinus spp

131

characteristics of twining model

blood chimerism is the norm in marmoset twins as functional vascular anastomosis between fetuses always occur. As in humnas, the freemartin condition does not occur

132

animal model of labor and pelvic organ prolapse

Saimiri spp

133

characteristics of labor and pelvic organ prolapse

fetal rotation occurs like in women,

134

animal model for Legionnaires' Disease

Callithrix jacchus

Macaca mulatta

Chlorocebus aethiops

(cavia porcellus most susceptible)

135

production of Legionnaires' model

production of small particle aerosol of L. pneumophila which mimics that inhaled by patients.

136

characteristics of Legionnaires' model

acute fibrinopurulent bronchopneumonia, organism survives and multiplies in lung macrophages

137

animal model for Ankylosing Spondylitis

aged Squirrel monkeys

138

characteristics of model for ankylosing spondylitis

signs usually in older animals, affected monkeys are reluctant to move, may refuse to rise and are likely to be attacked by cage mates. Spondylitis usually begins in sacroiliac joints.

139

animal model for cartilage allografts

Callithrix jacchus

140

characteristics of cartilage allografts

transplanted allografts of cultured mandibular condylar cartilage appeared to have the ability to promote cartilaginous repair and regeneration of orthopedic articular wounds

141

animal model for Syndactyly

Saguinus nigricollis

142

characteristics of Syndactyly model

abnormal soft tissue union of the digits, antosomal recessive trait

143

animal model for repetitive strain injury

Aotus spp

144

characteristics of repetitive strain injury model

Aotus monkeys are trained to repetitively open and close a handpiece. Animals that used a rapid, stereotypical hand squeezing technique developed a task-specific movement dysfunction. Animals that used a variable shoulder-pulling strategy did not develop movement problems

145

animal model for lead poisoining

Saimiri, Cebus

146

characteristics of lead poisoining model

occurs in infants with pica, signs similar to those seen in man. Notable difference is the presence of demylination in some simian brains and spinal cords not reported to occur to a significant degree in man. clinical signs are weakness, paralysis, amaurosis (vision loss or weakness that occurs without an apparent lesion affecting the eye)

147

animal model for Thalidomide syndrome

Callithrix jacchus

148

animal model for vesicoureteral reflux

NHP, but Rhesus are ideal

149

characteristics of vesicoureteral reflux model

NHPs show same low incidence of chronic phelonephritis and vesicoureteral reflux as pregnant women and infants

150

animal model of hydronephrosis of pregnancy

any NHP