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Flashcards in NW and OW NHP models Deck (209)
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animal model for Lissencephaly

Saimiri spp


characteristics of Lissencephaly model

Saimiri is highest species of primate with a lissencephalic brain, used to study cortical spreading depression in a highly encephalized brain


animal model for Viral Encephalitis and epilepsy

intracerebral injection with canine distemper virus (CDV), causes acute neurological signs of viral encephalitis such as seizures and myoclonus, lesions resemble childhood acute viral encephalitis and subacute sclerosing panencephalitis


animal model for Torticollis

Callithrix jacchus


characteristics of model for Torticollis

unilateral injection of 6-hydroxy-dopamine into the lateral hypothalamus resulted in persisting (days to weeks) severe torticollis with the head deviated toward the side of the lesion


animal model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

Cebus apella


characteristics of model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

in utero exposure to DES (diethylstilbestrol


animal model of Chlamydial infections

NW, OW, and great apes


characteristics of animal model of Chlamydial infections

Chlamydia trachomatis infection of primate genital tract, pathologic changes similar to humans. Owl monkey model for ocular trachoma


Trachoma is major blinding disease


animal model for Twinning, Chimerism, and immunologic tolerance

Callithrix and Saguinus spp


characteristics of twining model

blood chimerism is the norm in marmoset twins as functional vascular anastomosis between fetuses always occur. As in humnas, the freemartin condition does not occur


animal model of labor and pelvic organ prolapse

Saimiri spp


characteristics of labor and pelvic organ prolapse

fetal rotation occurs like in women,


animal model for Legionnaires' Disease

Callithrix jacchus

Macaca mulatta

Chlorocebus aethiops

(cavia porcellus most susceptible)


production of Legionnaires' model

production of small particle aerosol of L. pneumophila which mimics that inhaled by patients.


characteristics of Legionnaires' model

acute fibrinopurulent bronchopneumonia, organism survives and multiplies in lung macrophages


animal model for Ankylosing Spondylitis

aged Squirrel monkeys


characteristics of model for ankylosing spondylitis

signs usually in older animals, affected monkeys are reluctant to move, may refuse to rise and are likely to be attacked by cage mates. Spondylitis usually begins in sacroiliac joints.


animal model for cartilage allografts

Callithrix jacchus


characteristics of cartilage allografts

transplanted allografts of cultured mandibular condylar cartilage appeared to have the ability to promote cartilaginous repair and regeneration of orthopedic articular wounds


animal model for Syndactyly

Saguinus nigricollis


characteristics of Syndactyly model

abnormal soft tissue union of the digits, antosomal recessive trait


animal model for repetitive strain injury

Aotus spp


characteristics of repetitive strain injury model

Aotus monkeys are trained to repetitively open and close a handpiece. Animals that used a rapid, stereotypical hand squeezing technique developed a task-specific movement dysfunction. Animals that used a variable shoulder-pulling strategy did not develop movement problems


animal model for lead poisoining

Saimiri, Cebus


characteristics of lead poisoining model

occurs in infants with pica, signs similar to those seen in man. Notable difference is the presence of demylination in some simian brains and spinal cords not reported to occur to a significant degree in man. clinical signs are weakness, paralysis, amaurosis (vision loss or weakness that occurs without an apparent lesion affecting the eye)


animal model for Thalidomide syndrome

Callithrix jacchus


animal model for vesicoureteral reflux

NHP, but Rhesus are ideal


characteristics of vesicoureteral reflux model

NHPs show same low incidence of chronic phelonephritis and vesicoureteral reflux as pregnant women and infants


animal model of hydronephrosis of pregnancy

any NHP