Parasympathetic Inhibition (Anticholinergics) Flashcards Preview

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Flashcards in Parasympathetic Inhibition (Anticholinergics) Deck (11):
1

6 symptoms of parasympathetic, cholinergic blockade

1. Hot as a hare--> hyperthermia
2. Red as a beet--> flushing
3. Blind as a bat--> cycloplegia, mydriasis
4. Dry as a bone--> lack of salivation
5. Mad as a hatter--> confusion, delirium
6. Bloated as a toad--> constipation, urinary retention
7. Tachycardia

2

4 anticholinergics used in tx of urge-type urinary incontinence ("on the darn toilet")

1. Oxybutynin
2. Tolterodine
3. Darifinacin (and solifinacin)
4. Trospium

3

What are 5 pt populations that atropine is contraindicated?

1. BPH
2. Hyperthermia
3. ** Acute angle glaucoma
4. Elderly (exacerbate/ cause delirium)
5. G.I. obstruction or ileus

4

What are 4 other drugs/drug classes that have anticholinergic effects? *classic board Q to have an elderly person come into the ER with delirium due to these or mixing them

1. H1 blocking antihistamin (diphenyhydramine, doxylamine, chlorpheniramine)
2. Neuroleptics
3. TCA (often cause dry mouth)
4. Amantadine

5

4 drugs used topically to dilate pupils

1. atropine
2. homatropine
3. tropicamide
4. cyclopentolate

6

used in Parkinson's and used with antipsychotics to decrease side effects

Benzotropine (CNS)

7

motion sickness and also to decrease respiratory secretions in pts on respirator

Scopolamine

8

used in COPD and asthma

1. ipratropium
2. tiotropium

9

used preoperatively to reduce airway secretions

glycopyrrolate

10

reduces urgency in mild cystitis and reduces bladder spasms

oxybutynin

11

2 muscarinic antagonists that act in the CNS

1. benztropine
2. scopolamine

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