Pathophysiology of Joint Disease Flashcards Preview

Medicine, Year 2, Block 12 (Neurological, Neuromuscular, and MSK Diseases) > Pathophysiology of Joint Disease > Flashcards

Flashcards in Pathophysiology of Joint Disease Deck (26):
1

How long does Early Morning Stiffness of the hands last for in Osteoarthritis and in Rheumatoid arthritis?

Rheumatoid arthritis: > 30 mins
Osteoarthritis: < 30 mins

2

In five words, sum up the clinical presentation of Rheumatoid Arthritis

Chronic
Symmetrical
Inflammatory
Deforming
Polyarthritis

3

What is the primary site of inflammation of the Rheumatoid Arthritis?

Synovium

4

State two TNF-alpa inhibiting drugs used to treat Rheumatoid Arthritis

Infliximab
Adalimumab

5

What is "Sarcopenia"?

Loss of skeletal muscle mass and strength as a result of ageing

6

Give examples of three hand deformities as seen as Rheumatoid Arthritis

Swan neck
Boutonniere
Z-deformity of the thumb

7

What cytokines lead to the extra-articular manifestations of Rheumatoid Arthritis?

TNF-a
IL-1
IL-6

8

What joints do Rheumatoid Arthritis typically affect?

MCP / PIP joints

9

Give examples of 3 assays which can be used to support a diagnosis of Rheumatoid arthritis

- Rheumatoid Factor
- Antinuclear antibody
- Anti-CCP / Anti-MCV

10

What HLA-DR serotype is associated with Rheumatoid Arthritis?

HLA-DR4

11

What systemic symptoms are present in Rheumatoid Arthritis?

Fatigue
Low grade fever
Anorexia
Muscle / joint stiffness

12

What systemic symptoms are present in Osteoarthritis?

Absent

13

What is the age of onset for Rheumatoid Arthritis?

20 - 40 years

14

What is the age of onset for Osteoarthritis?

>50 years

15

What joints are affected in Osteoarthritis?

PIP / DIP joints
Large weight bearing joints i.e. hips / knees / spine

16

Radiologically, what might one see for a patient with Osteoarthritis?

Osteophytes
Joint space narrowing

17

In Osteoarthritis, is the synovial fluid clear or cloudy?

Clear

18

Gout affects what joint of the Hallux?

MTP joint (Podagra)

19

What are five modifiable risk factors for gout?

1. Hyperuricaemia
2. High purine diet (seafoods)
3. Alcohol intake (darker beers)
4. Obesity
5. Medication

20

What medications increase your likelihood of gout?

- Low dose aspirin
- Thiazide diuretics
- Furosemide
- Cyclosporin
- Ethambutol
- Levodopa
- Nicotinic acid

21

Gout is a disorder of what metabolism?

Purine metabolism

22

What gender is more susceptible to Gout?

Males

23

What gender is more susceptible to Osteoarthritis?

Females

24

State the name of 2 drugs used to treat Gout. What is its mechanism of action?

Allopurinol & Febuxostat

Xanthine Oxidase inhibitor

25

What are two complications of gout?

Tophaceous deposits
Renal stones

26

Define septic arthritis

The invasion of a joint by an infectious agent resulting in joint inflammation