Flashcards in Pathophysiology of Joint Disease Deck (26):
How long does Early Morning Stiffness of the hands last for in Osteoarthritis and in Rheumatoid arthritis?
Rheumatoid arthritis: > 30 mins
Osteoarthritis: < 30 mins
In five words, sum up the clinical presentation of Rheumatoid Arthritis
What is the primary site of inflammation of the Rheumatoid Arthritis?
State two TNF-alpa inhibiting drugs used to treat Rheumatoid Arthritis
What is "Sarcopenia"?
Loss of skeletal muscle mass and strength as a result of ageing
Give examples of three hand deformities as seen as Rheumatoid Arthritis
Z-deformity of the thumb
What cytokines lead to the extra-articular manifestations of Rheumatoid Arthritis?
What joints do Rheumatoid Arthritis typically affect?
MCP / PIP joints
Give examples of 3 assays which can be used to support a diagnosis of Rheumatoid arthritis
- Rheumatoid Factor
- Antinuclear antibody
- Anti-CCP / Anti-MCV
What HLA-DR serotype is associated with Rheumatoid Arthritis?
What systemic symptoms are present in Rheumatoid Arthritis?
Low grade fever
Muscle / joint stiffness
What systemic symptoms are present in Osteoarthritis?
What is the age of onset for Rheumatoid Arthritis?
20 - 40 years
What is the age of onset for Osteoarthritis?
What joints are affected in Osteoarthritis?
PIP / DIP joints
Large weight bearing joints i.e. hips / knees / spine
Radiologically, what might one see for a patient with Osteoarthritis?
Joint space narrowing
In Osteoarthritis, is the synovial fluid clear or cloudy?
Gout affects what joint of the Hallux?
MTP joint (Podagra)
What are five modifiable risk factors for gout?
2. High purine diet (seafoods)
3. Alcohol intake (darker beers)
What medications increase your likelihood of gout?
- Low dose aspirin
- Thiazide diuretics
- Nicotinic acid
Gout is a disorder of what metabolism?
What gender is more susceptible to Gout?
What gender is more susceptible to Osteoarthritis?
State the name of 2 drugs used to treat Gout. What is its mechanism of action?
Allopurinol & Febuxostat
Xanthine Oxidase inhibitor
What are two complications of gout?