Flashcards in Set 24 Micro Immuno Deck (46):
What are the phagocytic cells of the immune system?
neutrophils, monocytes, and macrophages
What are the inflammatory mediator cells?
basophils, mast cells, eosinophils
What is the function of cytokines?
activate helper and cytotoxic T cells, kill pathogen or tumor cells
What is the function of NK cells?
can inactivate pathogens
What is the function of Killer T cells?
kill virus-infected cells by triggering target cell suicide
What is the function of Helper T cells?
help in antigen recognition and regulation
What do helper T cells secrete?
What is an antigen?
target of antibodies and T cells
What is an epitope?
part of an antigen recognized by immune system
What is the function of CD4/Class I cells?
informs killer T cells of what is going on inside cells
What is the function of CD8/Class II cells?
informs helper T cells of problems outside cells
What is the function of an antibody?
tags an invader
What is Type I hypersensitivity?
immediate hypersensitivty (peanut, venom, penicilin) (outside in)
Which cells function in Type I hypersensitivity?
IgE, mast cells, basophils, allergic
Examples of Type I hypersensitivity:
anaphylaxis, hay fever, and asthma
What is Type II hypersensitivity?
antibody mediated (inside in)
Which cells function in Type II hypersensitivity?
IgG and IgM cause cell lysis
Examples of Type II hypersensitivity:
blood group incompatibility, pernicious anemia, myasthenia gravis
What is Type III hypersensitivity?
immune complex mediated (inside in)
Which cells function in Type III hypersensitivity?
IgG, antibody mediated inflammation, and some autoimmune
Examples of Type III hypersensitivity:
SLE, RA, serum sickness and rheumatic fever
What is Type IV hypersensitivity?
T cell mediated (outside in)
Examples of Type IV hypersensitivity:
infections, dermatitis, and graft rejections
When did SARS outbreak in China?
When did bird flu outbreak in Asia?
What is the most common food borne disease?
What is the second most common food borne disease?
How many new cases of TB?
How many deaths from TB?
What shape are bacilli?
What shape are cocci?
What shape are spirochetes?
What shape are spirilla?
What is mutualism?
What causes hay fever?
proteins from mold or plant spores
What causes asthma?
dust mites, cockroaches, rodents, and household pets
What is the process of asthma?
mast cells degranulate, histamine and other chemicals, IgE live 1 day, but weeks if attached to mast cells, basophils attach to IgE, and eosinophils have a chronic allergic reaction
What is Canale-Smith syndrome?
self reactive lymphocytes repeatedly stimulated, swollen lymph nodes
What is insulin-dependent diabetes mellitus?
organ specific immune disease - B cells target
What is myesthenia gravis?
self-reactive antibodies bind to ACh receptors
What is MS?
multiple sclerosis, CNS, self reactive T cells, myelin sheaths destroyed
What is the course of MS?
macrophages recruited by cytokines secreted by T cells, activated T cells can cross BBB
What is rheumatoid arthritis?
chronic joint inflammation
What is the course of RA?
IgM or IgG antibody activates macrophages, ^ inflammation
What is Lupus erythematosus?
red face rash, malar butterfly, inflammation of lungs, arthritis, kidney damage, hair loss, paralysis, and convultions