T3-Cancer Drugs Flashcards Preview

Pediatrics-MJ > T3-Cancer Drugs > Flashcards

Flashcards in T3-Cancer Drugs Deck (17)
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1
Q

What cancer drug has dose dependent neurotoxicity?

A

Vincristine

  • observe closely for signs so dosage may be reduced
  • Neurotoxicity may be permanent
2
Q

Vincristine may cause you to have dose dependent neurotoxicity. What is an early sign?

A

Do near checks frequently–Constipation is an early sign

3
Q

What drug do you need to monitor EKG, cardiac enzymes, and observe for cardiac decompensation?

A

Adriamycin

4
Q

What should we tell patients about adriamycin?

A

The drug causes a red discoloration of urine

life-time dose limit

5
Q

What are the SE to methotrexate? (MTX)

A

N/V

Stomatitis

6
Q

What must the urine pH be to give methotrexate? Why? What can be given following high doses?

A

pH 6.5 or greater (alkaline) during admin or MTX can precipitate in renal tubules

Leucovorin

7
Q

What drug has these adverse effects:

  • High BP
  • Hyperglycemia
  • Gastric bleeding, ulceration
  • Increased appetite
  • Delayed healing
  • Increased risk of infection
  • Body appearance changes: Trunkal obesity and cushioned features (round face, hirsutism)
A

Prednisone

8
Q

What drug do you need to have good hydration prior to and during oral and IV admin. What is important about night time with this drug?

A

Cytoxan—bladder must be emptied frequently, even at night

9
Q

What drug should we be alert to possibility of allergic reactions and prepared to treat? *we should give a test dose prior to them starting this drug?

A

L-Asparaginase

10
Q

What is adriamycins adverse effect?

A

Cardiotoxicity: dose related, EKG changes, arrhythmia, CHF

11
Q

What is the adverse effect and nursing implications for mercaptopurine (6-MP)?

A

Hyperuricemia

Monitor uric acid levels

Allopurinol may be given to reduce uric acid levels

12
Q

What is the adverse effect of cytoxan (cyclophosphamine)?

A

Hemorrhagic cystitis

*good hydration!!

13
Q

What is neurotoxicity and what drug has this as an adverse effect?

A

Neurotoxicity:

  • Foot, wrist drop
  • Vocal cord paralysis
  • Hoarseness
  • Ptosis
  • Ataxia
  • Muscle weakness
  • Paresthesia
  • Constipation
  • Paralytic ileus

Drug: Vincristine

14
Q

What drug has protein hypersensitivity? What is protein hypersentivity? And what is nursing implication?

A

L-asparaginase

Protein hypersensitivity: pruitis, urticaria, bronchial spasm, edema (of neck and lips), anaphylaxis

Be alert to allergic reactions

15
Q

What is the nursing action for prednisone?

A

Monitor BP, distress, and bleeding
Be alert to signs of infection
Observe for gastric bleeding

16
Q

What drug should we give with food or milk or an antacid?

A

Prednisone

17
Q

What should we know about drug Leucovorin?

A

It is a rescue drug that must follow high doses of MTX because MTX can precipitate in renal tubules

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