Flashcards in T3-Cancer Drugs Deck (17):
What cancer drug has dose dependent neurotoxicity?
*observe closely for signs so dosage may be reduced
-Neurotoxicity may be permanent
Vincristine may cause you to have dose dependent neurotoxicity. What is an early sign?
Do near checks frequently--Constipation is an early sign
What drug do you need to monitor EKG, cardiac enzymes, and observe for cardiac decompensation?
What should we tell patients about adriamycin?
The drug causes a red discoloration of urine
life-time dose limit
What are the SE to methotrexate? (MTX)
What must the urine pH be to give methotrexate? Why? What can be given following high doses?
pH 6.5 or greater (alkaline) during admin or MTX can precipitate in renal tubules
What drug has these adverse effects:
-Gastric bleeding, ulceration
-Increased risk of infection
-Body appearance changes: Trunkal obesity and cushioned features (round face, hirsutism)
What drug do you need to have good hydration prior to and during oral and IV admin. What is important about night time with this drug?
Cytoxan---bladder must be emptied frequently, even at night
What drug should we be alert to possibility of allergic reactions and prepared to treat? *we should give a test dose prior to them starting this drug?
What is adriamycins adverse effect?
Cardiotoxicity: dose related, EKG changes, arrhythmia, CHF
What is the adverse effect and nursing implications for mercaptopurine (6-MP)?
Monitor uric acid levels
Allopurinol may be given to reduce uric acid levels
What is the adverse effect of cytoxan (cyclophosphamine)?
What is neurotoxicity and what drug has this as an adverse effect?
-Foot, wrist drop
-Vocal cord paralysis
What drug has protein hypersensitivity? What is protein hypersentivity? And what is nursing implication?
Protein hypersensitivity: pruitis, urticaria, bronchial spasm, edema (of neck and lips), anaphylaxis
Be alert to allergic reactions
What is the nursing action for prednisone?
Monitor BP, distress, and bleeding
Be alert to signs of infection
Observe for gastric bleeding
What drug should we give with food or milk or an antacid?