T3-Cancer Drugs Flashcards Preview

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Flashcards in T3-Cancer Drugs Deck (17):
1

What cancer drug has dose dependent neurotoxicity?

Vincristine

*observe closely for signs so dosage may be reduced
-Neurotoxicity may be permanent

2

Vincristine may cause you to have dose dependent neurotoxicity. What is an early sign?

Do near checks frequently--Constipation is an early sign

3

What drug do you need to monitor EKG, cardiac enzymes, and observe for cardiac decompensation?

Adriamycin

4

What should we tell patients about adriamycin?

The drug causes a red discoloration of urine

life-time dose limit

5

What are the SE to methotrexate? (MTX)

N/V
Stomatitis

6

What must the urine pH be to give methotrexate? Why? What can be given following high doses?

pH 6.5 or greater (alkaline) during admin or MTX can precipitate in renal tubules

Leucovorin

7

What drug has these adverse effects:

-High BP
-Hyperglycemia
-Gastric bleeding, ulceration
-Increased appetite
-Delayed healing
-Increased risk of infection
-Body appearance changes: Trunkal obesity and cushioned features (round face, hirsutism)

Prednisone

8

What drug do you need to have good hydration prior to and during oral and IV admin. What is important about night time with this drug?

Cytoxan---bladder must be emptied frequently, even at night

9

What drug should we be alert to possibility of allergic reactions and prepared to treat? *we should give a test dose prior to them starting this drug?

L-Asparaginase

10

What is adriamycins adverse effect?

Cardiotoxicity: dose related, EKG changes, arrhythmia, CHF

11

What is the adverse effect and nursing implications for mercaptopurine (6-MP)?

Hyperuricemia

Monitor uric acid levels

Allopurinol may be given to reduce uric acid levels

12

What is the adverse effect of cytoxan (cyclophosphamine)?

Hemorrhagic cystitis

*good hydration!!

13

What is neurotoxicity and what drug has this as an adverse effect?

Neurotoxicity:
-Foot, wrist drop
-Vocal cord paralysis
-Hoarseness
-Ptosis
-Ataxia
-Muscle weakness
-Paresthesia
-Constipation
-Paralytic ileus

Drug: Vincristine

14

What drug has protein hypersensitivity? What is protein hypersentivity? And what is nursing implication?

L-asparaginase


Protein hypersensitivity: pruitis, urticaria, bronchial spasm, edema (of neck and lips), anaphylaxis

Be alert to allergic reactions

15

What is the nursing action for prednisone?

Monitor BP, distress, and bleeding
Be alert to signs of infection
Observe for gastric bleeding

16

What drug should we give with food or milk or an antacid?

Prednisone

17

What should we know about drug Leucovorin?

It is a rescue drug that must follow high doses of MTX because MTX can precipitate in renal tubules

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