4.3.1 Tumor markers Flashcards by Miguel Acosta | Brainscape

Q

Characteristics of an ideal tumor marker:

Should be Cancer-Sensitive and Tissue specific

T or F

A

T

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Q

Characteristics of an ideal tumor marker:

Shows elevation at the late stage of cancer

T or F

A

F

Early

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Q

Characteristics of an ideal tumor marker:

Serum levels correlate with tumor burden

T or F

A

T

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Q

Tumor markers can be use as stand alone test

T or F

A

F

Requires other test

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Q

Pancreatic

a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1

A

d

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Q

Liver

a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1

A

a

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Q

Colorectal

a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1

A

b

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Q

Breast

a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1

A

c

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Q

Increase in germ cell tumors

a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1

A

a

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Q

Related to lewis Blood group antigens

a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1

A

d

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Q

Increase in gastric and colorectal cancer

a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1

A

d

Same with CA 72-4 and CEA

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Q

Breast

a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu

A

d

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Q

Ovarian

a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu

A

b

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Q

Gastric

a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu

A

a

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Q

Lung

a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu

A

c

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Q

Increase in colorectal cancer

a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu

A

a

Q

Increase with Gynecological conditions

a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu

A

b

Q

Subunit of Cytokeratin fragment

a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu

A

c

Q

Urinary bladder

a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin

A

b

Q

Prostatic

a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin

A

a

Q

Thyroid

a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin

A

d

Q

Ovarian / Testicular

a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin

A

c

Q

Used for screening in combination with DRE

a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin

A

a

Q

Oncogene-encoded protein

a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin

A

b

Q

Neuroblastoma

a. HVA, VMA
b. MN, nMN

A

a

Q

Phaeochromocytoma

a. HVA, VMA
b. MN, nMN

A

b

Q

24-h urine; HPLC

a. HVA, VMA
b. MN, nMN

A

a

Q

24-h urine OR plasma ; HPLC

a. HVA, VMA
b. MN, nMN

A

b

Q

For catecholamines

a. Immunoassay
b. HPLC
c. Enzyme assays
d. Immunohistochemistry

A

b

Q

For receptor markers

a. Immunoassay
b. HPLC
c. Enzyme assays
d. Immunohistochemistry

A

d

Q

Gestational Thromboplastic disease/aplasia

a. Immunoassay
b. HPLC
c. Enzyme assays
d. Immunohistochemistry

A

d

Q

Tumor markers:

CEA can correlate with CA 72-4 since it can detect colorectal

T or F

A

T

Q

CA 125 and beta hCG is almost the same because the tumor type is ovarian

T or F

A

T

CA 125: Ovarian
beta hCG: Ovarian/Testicular