3.2.2.1 Clinical Enzymology (Lactate Dehydrogenase)

Question 1

Lactate dehydrogenase (LDH) is the most ubiquitous since it can be produce by several tissues

T or F

Answer 1

T

Question 2

Since LDH is ubiquitous, it is the least specific since you don’t know where it can be produce

T or F

Answer 2

T

Question 3

LDH is a tetra peptide meaning, it consist of ____ peptide unit

Answer 3

4

ex:

H4
H3M1

Question 4

Major tissue source:

Lungs, lymphocytes, spleen, pancreas

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 4

c

Question 5

Major tissue source:

Liver, skeletal muscles

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 5

d and e

Question 6

Major tissue source:

Heart, RBCs, renal cortex

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 6

a and b

Question 7

H4

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 7

a

Question 8

H3M1

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 8

b

Question 9

H2M2

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 9

c

Question 10

M4

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 10

e

Question 11

H1M3

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 11

d

Question 12

Most anodal (Fastest)

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 12

a

Question 13

Most Cathodal (Slowest)

a. LD1
b. LD2
c. LD3
d. LD4
e. LD5

Answer 13

e

Question 14

LD2 is abundant than LD1

T or F

Answer 14

F

LD1 is mostly abundant than LD2

Question 15

Normal serum ratio:

LD2 > LD1

T or F

Answer 15

T

Question 16

Flipped ration in SERUM:

LD1 > LD2

T or F

Answer 16

T

Question 17

Does flipped Serum ratio indicate damage such as hemolytic anemia, MI, and Renal inflammation?

T or F

Answer 17

LD1 is inside that particular organ and due to injury, it release into the serum which is the reason why LD1 is greater than LD2

Question 18

Associated with:
arteriosclerotic, cardiovascular failure, CATHODIC to LD5 (Slower the LD5) signifying grave prognosis and impending death

Answer 18

LD6

Question 19

> 5 x

a. Pronounced elevation
b. Moderate elevation
c. Slight elecation

Answer 19

a

Question 20

> 3 x

a. Pronounced elevation
b. Moderate elevation
c. Slight elecation

Answer 20

b

Question 21

Up to 3 x

a. Pronounced elevation
b. Moderate elevation
c. Slight elecation

Answer 21

c

Question 22

Highest LD elevation (Pronounced elevation)

a. Hemolysis
b. Renal infarction
c. Systemic shock
d. Megaloblastic anemia

Answer 22

d

Question 23

What is the hematologic defect of megaloblastic anemia due to a deficiency in Vit B12?

a. Cytoplasm matures first then nucleus (asynchronous)
b. Impair synthesis
c. Ineffective erythropoiesis
d. All of the above

Answer 23

c

Production of RBC is not released properly due to RBCs being destroyed in the bone marrow

RULE of the Bone Marrow:
if you are abnormal, you are not release

Question 24

Myocardial Infarction, Hemolytic conditions, pulmonary infarction, muscular dystrophy, delirium tremens, leukemias, IM

a. Pronounced elevation
b. Moderate elevation
c. Slight elevation

Answer 24

b

Question 25

Most liver diseases, nephrotic syndrome, hypothyroidism, cholangitis

a. Pronounced elevation
b. Moderate elevation
c. Slight elecation

Answer 25

c