3.2.3.1 Clinical Enzymology (Aminotransferases/Transaminases) Flashcards

1
Q

Tissue sources includes:
- Liver

a. Creatinine kinase
b. Lactate dehydrogenase
c. AST / SGOT
d. ALT / SGPT

A

d

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2
Q

Tissue sources includes:
- Liver
- Heart
- Skeletal Muscle

a. Creatinine kinase
b. Lactate dehydrogenase
c. AST / SGOT
d. ALT / SGPT

A

c

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3
Q

Acute hepatocellular disorders (More specific, higher and more sustained elevation

a. AST / SGOT
b. ALT / SGPT

A

b

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4
Q

Due to ALT having higher elevation and sustained, the half-life of this is ________

A

longer

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5
Q

De ritis ratio:

a. <1 (AST/ALT)
b. <2 (AST/ALT)
c. <3 (AST/ALT)
d. <4 (AST/ALT)

A

a

If ALT is higher, the lower the ratio

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6
Q

Pronounced diagnosis in AST is usually what organ?

a. Liver
b. Heart
c. Skeletal muscle

A

a and b

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7
Q

AST:

Acute hepatocellular disorders, circulatory collapse, myocardial infarction

a. Pronounced
b. Moderate
c. Slight

A

a

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8
Q

AST:

Muscular dystrophy

a. Pronounced
b. Moderate
c. Slight

A

b

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9
Q

Release where there is tissue damage

a. Cytoplasmic AST
b. Mitochondrial AST

A

a

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10
Q

Release when there extensive tissue damage

a. Cytoplasmic AST
b. Mitochondrial AST

A

b

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11
Q

Increase in hepatic failure and alcoholic liver disease which is an exception to De ritis since it is Greater than 1

a. Cytoplasmic AST
b. Mitochondrial AST

A

b

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12
Q

Has the longest half life among aminotransferase

a. Cytoplasmic AST
b. Mitochondrial AST
c. ALT

A

b

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13
Q

The sequence of half-life in Aminotransferases from longest to shortest

a. ASTc
b. ALT
c. ASTm

A

c,b,a

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14
Q

If mitochondrial AST is high, the De ritis ratio is High

T or F

A

T

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15
Q

IF De ritis is more than 1 what is the clinical significance?

a. Hepatic failure
b. Alcoholic liver disease
c. All of the above

A

c

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