3.2.3.1 Clinical Enzymology (Aminotransferases/Transaminases) Flashcards
Tissue sources includes:
- Liver
a. Creatinine kinase
b. Lactate dehydrogenase
c. AST / SGOT
d. ALT / SGPT
d
Tissue sources includes:
- Liver
- Heart
- Skeletal Muscle
a. Creatinine kinase
b. Lactate dehydrogenase
c. AST / SGOT
d. ALT / SGPT
c
Acute hepatocellular disorders (More specific, higher and more sustained elevation
a. AST / SGOT
b. ALT / SGPT
b
Due to ALT having higher elevation and sustained, the half-life of this is ________
longer
De ritis ratio:
a. <1 (AST/ALT)
b. <2 (AST/ALT)
c. <3 (AST/ALT)
d. <4 (AST/ALT)
a
If ALT is higher, the lower the ratio
Pronounced diagnosis in AST is usually what organ?
a. Liver
b. Heart
c. Skeletal muscle
a and b
AST:
Acute hepatocellular disorders, circulatory collapse, myocardial infarction
a. Pronounced
b. Moderate
c. Slight
a
AST:
Muscular dystrophy
a. Pronounced
b. Moderate
c. Slight
b
Release where there is tissue damage
a. Cytoplasmic AST
b. Mitochondrial AST
a
Release when there extensive tissue damage
a. Cytoplasmic AST
b. Mitochondrial AST
b
Increase in hepatic failure and alcoholic liver disease which is an exception to De ritis since it is Greater than 1
a. Cytoplasmic AST
b. Mitochondrial AST
b
Has the longest half life among aminotransferase
a. Cytoplasmic AST
b. Mitochondrial AST
c. ALT
b
The sequence of half-life in Aminotransferases from longest to shortest
a. ASTc
b. ALT
c. ASTm
c,b,a
If mitochondrial AST is high, the De ritis ratio is High
T or F
T
IF De ritis is more than 1 what is the clinical significance?
a. Hepatic failure
b. Alcoholic liver disease
c. All of the above
c