3.2.4.1 Clinical Enzymology (Alkaline Phosphatase) Flashcards

1
Q

Tissue sources includes:
- Liver
- Bone
- Placenta
- Intestine

a. Creatinine kinase
b. Lactate dehydrogenase
c. Aminotransferase
d. Alkaline phosphatase
e. Amylase
f. Lipase

A

d

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2
Q

Pronounced Elevation of ALP is mostly on what organ?

A

Liver and bone

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3
Q

Hepative biliary Disorders (Bile duct obstruction, biliary cirrhosis), Paget’s disease, Osteogenic sarcoma, hyperparathyroidism

a. Pronounced
b. Moderate
c. Slight

A

a

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4
Q

The source of Highest ALP elevation?

a. HBO
b. Paget’s Disease
c. hyperparathyroidism
d. Osteosarcoma

A

b

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5
Q

Rickets and osteomalacia

a. Pronounced
b. Moderate
c. Slight

A

b

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5
Q

Rickets and osteomalacia are the consequence of Vitamin ___ deficiency

A

D

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6
Q

Healing bone fractures, growing children

a. Pronounced
b. Moderate
c. Slight

A

c

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7
Q

Pregnancy (Placenta)

a. Pronounced
b. Moderate
c. Slight

A

c

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8
Q

Placenta ALP ONLY Contributes during Pregnancy

T or F

A

T

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9
Q

Isoenzyme analysis base on Electrophoresis:

Arrange from Cathodal to Anodal
a. Liver
b. Bone
c. Placenta
d. Intestine

A

a,b,c,d

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10
Q

Isoenzyme analysis base on Heat stability:

Arrange from Most heat stable to the least

a. Liver
b. Bone
c. Placenta
d. Intestine

A

c,d,a,b

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11
Q

In Heat stability:

Bone ALP, <20% activity at _______

a. 65C
b. 56C
c. 50C
d. 70C

A

b

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12
Q

In Heat stability:

Placental ALP Resist heating at _______ for _______

a. 65C, 30 mins
b. 56C, 30 mins
c. 65C, 30 sec
d. 56C, 30 sec

A

a

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13
Q

Isoenzyme analysis base on Chemical inhibition:

Urea is most notable since it inhibits one isoenzyme which is?

a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental

A

b

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14
Q

Isoenzyme analysis base on Chemical inhibition:

Levamisole inhibits?

a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental

A

a and b

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15
Q

Isoenzyme analysis base on Chemical inhibition:

Phenylalanine inhibits?

a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental

A

c, e and d

16
Q

Isoenzyme analysis base on Chemical inhibition:

Associated with B or O secretors which are increased after consumption of a fatty meal

a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental

A

d

Intestinal ALP

17
Q

Carcinoplacental is a nonspecific tumor marker that abnormally produces isoenzymes

T or F

A

T

18
Q

Most heat stable than normal Isoenzymes

a. Regan
b. Nagao
c. Kasahara

A

a

19
Q

Inhibited by phenylalanine

a. Regan
b. Nagao
c. Kasahara

A

All

20
Q

Variant of Regan

a. Regan
b. Nagao
c. Kasahara

A

b

21
Q

Inhibited by leucine

a. Regan
b. Nagao
c. Kasahara

A

b

22
Q

Associated with hepatic and GI tumors

a. Regan
b. Nagao
c. Kasahara

A

c