2.5.3 Assessment of Liver Function (Bilirubin Metabolism) Flashcards
Bilirubin (B1) is first transported in the portal system, bound mainly to?
a. Albumin
b. Urobilinogen
c. Iron
d.RBC
a
Upon entering the hepatocyte, B1 is transported to ___________ where it is conjugated in the presence of the enzyme?
a. Rougn ER, UDPGT
b. Smooth ER, UDPGT
c. Rough ER, UPDGT
d. Smooth ER, UPDGT
b
uridyl diphosphoglucuronyl transferase (UDPGT)
Conjugated bilirubin (B2) is then ___________ to bile canaliculi and _________ to the intestinal tract
Secreted
Excreted
B2 is further metabolized in the small intestine by the bacteria into _________
Urobilinogen
Majority of urobilinogen is reabsorbed and re-excreted by the liver so the minor fraction is excreted in the __________
Urine
The intestinal urobilinogen in converted into stool pigment called?
Urobilin