2.5.2 Assessment of Liver Function (Forms of Bilirubin in Plasma) Flashcards

1
Q

Origin: Pre-hepatic/Hemolytic
Structure: Unconjugated

a. B1
b. B2

A

a

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2
Q

Origin: Post-hepatic/Obstructive
Structure: Conjugated

a. B1
b. B2

A

b

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3
Q

Solubility: Insoluble
Polarity: Nonpolar

a. B1
b. B2

A

a

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4
Q

Solubility: Soluble
Polarity: Polar

a. B1
b. B2

A

b

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5
Q

Reaction: Direct

a. B1
b. B2

A

b

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6
Q

Reaction: Indirect (Requires accelerator)

a. B1
b. B2

A

a

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7
Q

Excreted in urine: No
Affinity for CNS: Yes

a. B1
b. B2

A

a

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8
Q

Excreted in urine: Yes
Affinity for CNS: No

a. B1
b. B2

A

b

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9
Q

Derived from the destruction of RBCs

a. B1
b. B2

A

a

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10
Q

Causes kernictus

a. B1
b. B2

A

a

Affinity to CNS

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11
Q

What do you call a B2 that is bound to albumin?

A

Delta bilirubin

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12
Q

Half-life of delta bilirubin?

A

17 days (Similar to albumin)

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13
Q

Delta bilirubin is seen in cases of?

A

Biliary obstruction

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14
Q

Reaction with diazo reagent?

A

Direct

Similar to B2

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15
Q

Separated from other fractions by?

A

HPLC

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