2.5.2 Assessment of Liver Function (Forms of Bilirubin in Plasma) Flashcards
Origin: Pre-hepatic/Hemolytic
Structure: Unconjugated
a. B1
b. B2
a
Origin: Post-hepatic/Obstructive
Structure: Conjugated
a. B1
b. B2
b
Solubility: Insoluble
Polarity: Nonpolar
a. B1
b. B2
a
Solubility: Soluble
Polarity: Polar
a. B1
b. B2
b
Reaction: Direct
a. B1
b. B2
b
Reaction: Indirect (Requires accelerator)
a. B1
b. B2
a
Excreted in urine: No
Affinity for CNS: Yes
a. B1
b. B2
a
Excreted in urine: Yes
Affinity for CNS: No
a. B1
b. B2
b
Derived from the destruction of RBCs
a. B1
b. B2
a
Causes kernictus
a. B1
b. B2
a
Affinity to CNS
What do you call a B2 that is bound to albumin?
Delta bilirubin
Half-life of delta bilirubin?
17 days (Similar to albumin)
Delta bilirubin is seen in cases of?
Biliary obstruction
Reaction with diazo reagent?
Direct
Similar to B2
Separated from other fractions by?
HPLC