2.5.2 Assessment of Liver Function (Forms of Bilirubin in Plasma)

Question 1

Origin: Pre-hepatic/Hemolytic
Structure: Unconjugated

a. B1
b. B2

Answer 1

a

Question 2

Origin: Post-hepatic/Obstructive
Structure: Conjugated

a. B1
b. B2

Answer 2

b

Question 3

Solubility: Insoluble
Polarity: Nonpolar

a. B1
b. B2

Answer 3

a

Question 4

Solubility: Soluble
Polarity: Polar

a. B1
b. B2

Answer 4

b

Question 5

Reaction: Direct

a. B1
b. B2

Answer 5

b

Question 6

Reaction: Indirect (Requires accelerator)

a. B1
b. B2

Answer 6

a

Question 7

Excreted in urine: No
Affinity for CNS: Yes

a. B1
b. B2

Answer 7

a

Question 8

Excreted in urine: Yes
Affinity for CNS: No

a. B1
b. B2

Answer 8

b

Question 9

Derived from the destruction of RBCs

a. B1
b. B2

Answer 9

a

Question 10

Causes kernictus

a. B1
b. B2

Answer 10

a

Affinity to CNS

Question 11

What do you call a B2 that is bound to albumin?

Answer 11

Delta bilirubin

Question 12

Half-life of delta bilirubin?

Answer 12

17 days (Similar to albumin)

Question 13

Delta bilirubin is seen in cases of?

Answer 13

Biliary obstruction

Question 14

Reaction with diazo reagent?

Answer 14

Direct

Similar to B2

Question 15

Separated from other fractions by?

Answer 15

HPLC