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MTAP 1 Clinical Chemistry > 2.5.4 Assessment of Liver Function (Derangements of Bilirubin Metabolism) > Flashcards

2.5.4 Assessment of Liver Function (Derangements of Bilirubin Metabolism) Flashcards

1
Q

Increase B1, Decrease delivery and uptake or a conjugation

a. Unconjugated hyperbilirubinemia
b. Conjugated hyperbilirubinemia
c. Mixed hyperbilirubinemia

A

a

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2
Q

Increase B2 due to intrahepatic or extrahepatic cholestasis

a. Unconjugated hyperbilirubinemia
b. Conjugated hyperbilirubinemia
c. Mixed hyperbilirubinemia

A

b

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3
Q

Increase B1 and B2 due to a combination of defects

a. Unconjugated hyperbilirubinemia
b. Conjugated hyperbilirubinemia
c. Mixed hyperbilirubinemia

A

c

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4
Q

Serum Bil: Increased B1
Urine Bil: Neg
Urine UroBil: 3+

a. Pre-hepatic/Hemolytic
b. Hepatic
c. Post-hepatic/Obstructive

A

a

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5
Q

Serum Bil: Increased B2
Urine Bil: 3+
Urine UroBil: Normal (RST)

a. Pre-hepatic/Hemolytic
b. Hepatic
c. Post-hepatic/Obstructive

A

c

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6
Q

Serum Bil: Increased B1 and B2
Urine Bil: (+) if B2 or both / (-) if B1
Urine UroBil: 2+

a. Pre-hepatic/Hemolytic
b. Hepatic
c. Post-hepatic/Obstructive

A

b

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7
Q

Crigler-Najjar syndrome, Lucey-Driscoll syndrome, Physiologic jaundice of the newborn, and Gilbert syndrome

a. Increased B1
b. Increased B2
c. Increased B1 and B2

A

a

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8
Q

Dubin-Johnson syndrome

a. Increased B1
b. Increased B2
c. Increased B1 and B2

A

b

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9
Q

Hepatitis, cirrhosis, and hepatic carcinoma

a. Increased B1
b. Increased B2
c. Increased B1 and B2

A

c

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10
Q

B1 Can be seen in urine

T or F

A

F

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11
Q

Urobilinogen in the urine is increased when:

a. Less B1
b. Impede recirculation pathway
c. Abnormalities in Albumin
d. All of the above

A

b

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12
Q

Hemolytic anemia may cause increase in urobilinogen in the urine

T or F

A

T

Since Bilirubin is increased when RBCs are destroyed, the liver will overwork itself and may not take up urobilinogen

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13
Q

Liver disease may increase urobilinogen

A

T

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14
Q

In post hepatic, urobilinogen will no be exceted due to blockage in excretory path so the result for urobilinogen in the urine is?

A

Normal

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15
Q

Gilbert syndrome

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

b

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16
Q

Viral hepatitis, Cirrhosis, Hepativ carcinoma

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

c

17
Q

Lucey-Driscoll syndrome

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

b

18
Q

Physiologic jaundice of the newborn

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

b

19
Q

Crigler-Najjar syndrome

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

b

20
Q

Biliary obstruction

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

e

21
Q

Dubin Johnson syndrome

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

d

22
Q

Rotor syndrome

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

d

23
Q

Due to secretory defect

a. Hemolytic disease
b. Viral hepatitis, cirrhosis, Hepatic carcinoma
c. Dubin-Johnson and Rotor syndrome
d. Biliary obstruction

A

c

24
Q

Extrahepatic cholestasis

a. Hemolytic disease
b. Viral hepatitis, cirrhosis, Hepatic carcinoma
c. Dubin-Johnson and Rotor syndrome
d. Biliary obstruction

A

d

25
Q

Increase RBCs destruction = Increase bilirubin production

a. Hemolytic disease
b. Viral hepatitis, cirrhosis, Hepatic carcinoma
c. Dubin-Johnson and Rotor syndrome
d. Biliary obstruction

A

a

26
Q

Increase B1 = Decrease conjugatio

Increase B2 = Bile flow interference

a. Hemolytic disease
b. Viral hepatitis, cirrhosis, Hepatic carcinoma
c. Dubin-Johnson and Rotor syndrome
d. Biliary obstruction

A

b

27
Q

Transport Defect (Mild UDPGT deficiency)

a. Gilbert syndrome
b. Lucey-Driscoll syndrome
c. Physiologic jaundice of the newborn
d. Crigler-Najjar syndrome

A

a

28
Q

Circulating inhibitor of bilirubin conjugation

a. Gilbert syndrome
b. Lucey-Driscoll syndrome
c. Physiologic jaundice of the newborn
d. Crigler-Najjar syndrome

A

b

29
Q

Transient UDPGT deficiency

a. Gilbert syndrome
b. Lucey-Driscoll syndrome
c. Physiologic jaundice of the newborn
d. Crigler-Najjar syndrome

A

c

30
Q

Total or partial UDPGT deficiency

a. Gilbert syndrome
b. Lucey-Driscoll syndrome
c. Physiologic jaundice of the newborn
d. Crigler-Najjar syndrome

A

d

31
Q

B1: Increased
B2: Normal

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

a and b

32
Q

B1: Increased
B2: Increased

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

c

33
Q

B1: Normal - Increased
B2: Increased

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

d

34
Q

B1: Normal
B2: Increased

a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated

A

e

35
Q

How to differentiate Dubin-Johnson syndrome and Rotor syndrome?

A

Dark pigmentation in hepatocyte

MTAP 1 Clinical Chemistry (97 decks)

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