2.5.4 Assessment of Liver Function (Derangements of Bilirubin Metabolism) Flashcards
Increase B1, Decrease delivery and uptake or a conjugation
a. Unconjugated hyperbilirubinemia
b. Conjugated hyperbilirubinemia
c. Mixed hyperbilirubinemia
a
Increase B2 due to intrahepatic or extrahepatic cholestasis
a. Unconjugated hyperbilirubinemia
b. Conjugated hyperbilirubinemia
c. Mixed hyperbilirubinemia
b
Increase B1 and B2 due to a combination of defects
a. Unconjugated hyperbilirubinemia
b. Conjugated hyperbilirubinemia
c. Mixed hyperbilirubinemia
c
Serum Bil: Increased B1
Urine Bil: Neg
Urine UroBil: 3+
a. Pre-hepatic/Hemolytic
b. Hepatic
c. Post-hepatic/Obstructive
a
Serum Bil: Increased B2
Urine Bil: 3+
Urine UroBil: Normal (RST)
a. Pre-hepatic/Hemolytic
b. Hepatic
c. Post-hepatic/Obstructive
c
Serum Bil: Increased B1 and B2
Urine Bil: (+) if B2 or both / (-) if B1
Urine UroBil: 2+
a. Pre-hepatic/Hemolytic
b. Hepatic
c. Post-hepatic/Obstructive
b
Crigler-Najjar syndrome, Lucey-Driscoll syndrome, Physiologic jaundice of the newborn, and Gilbert syndrome
a. Increased B1
b. Increased B2
c. Increased B1 and B2
a
Dubin-Johnson syndrome
a. Increased B1
b. Increased B2
c. Increased B1 and B2
b
Hepatitis, cirrhosis, and hepatic carcinoma
a. Increased B1
b. Increased B2
c. Increased B1 and B2
c
B1 Can be seen in urine
T or F
F
Urobilinogen in the urine is increased when:
a. Less B1
b. Impede recirculation pathway
c. Abnormalities in Albumin
d. All of the above
b
Hemolytic anemia may cause increase in urobilinogen in the urine
T or F
T
Since Bilirubin is increased when RBCs are destroyed, the liver will overwork itself and may not take up urobilinogen
Liver disease may increase urobilinogen
T
In post hepatic, urobilinogen will no be exceted due to blockage in excretory path so the result for urobilinogen in the urine is?
Normal
Gilbert syndrome
a. Pre-hepative, unconjugated
b. Hepatic, unconjugated
c. Hepatic, mixed
d. Hepatic, Conjugated or mixed
e. Post-hepatic conjugated
b