2.7.4 Tertiary Structure Flashcards
1
Q
tertiary structure
A
- of a protein is the three-dimensional folding that results from interactions between R groups.
2
Q
note
A
- Several major interactions take place between R groups: hydrophobic interactions, Van der Waals interactions, ionic bonding, and formation of disulfide bridges.
3
Q
hydrophobic interactions
A
- take place when amino acids with hydrophobic (nonpolar) R groups come together into the interior of a molecule to minimize contact with water.
4
Q
Van der Waals interactions
A
- As the hydrophobic R groups pack together, Van der Waals interactions between atoms in R groups reinforce their interactions
5
Q
ionic bonding
A
- takes place between charged R groups because of the attraction between positive and negative charges
6
Q
disulfide bridges
A
- strong covalent bonds that form between two cysteine molecules. Cysteine has a sulfhydril group that can form a disulfide bond when placed next to another sulfhydril group.
7
Q
hydrogen bonds
A
- may also participate in stabilizing the tertiary structure.
8
Q
Two proteins composed of exactly the same numbers and types of amino acids, but very different sequences, may differ in
A
- tertiary structure, secondary structure, biological activity
9
Q
Disulfide bridges form between
A
- two cysteines
10
Q
Which of the following types of covalent bonds contributes to the tertiary structure of a protein?
A
- disulfide bonds
11
Q
The __________ structure refers to the way a protein folds upon itself
A
- tertiary
12
Q
What part do Van der Waals forces play in the tertiary structure of a protein?
A
- they are involved in attraction between nonpolar R groups in the protein interior
13
Q
Which of the following amino acids would most likely be found in the interior of a globular protein that exists in the cytosol of a cell?
A
- isoleucine
