2.9.2 Enzyme Regulation: Allosteric Regulation

Question 1

allosteric regulation

Answer 1

• causes an enzyme to oscillate between an active and inactive form
• type of enzyme regulation that uses molecules to inhibit or activate the enzyme by binding to it at a place other than the active site

Question 2

activators

Answer 2

• substances that bind to the enzyme and keep it in an active state

Question 3

inhibitors

Answer 3

• molecules that bind to the enzyme to keep it in an inactive state

Question 4

Molecules that are similar in shape to an enzyme substrate but are nonreactive if they bind to the active site are

Answer 4

• competitive inhibitors

Question 5

True or false?

An allosteric site is a binding region on an enzyme other than the active site.

Answer 5

• true

Question 6

Allosteric regulation occurs when

Answer 6

• a molecule binds to an area other than the active site of the enzyme and prevents it from assuming the conformation necessary to bind substrate

Question 7

Which type of inhibitor always binds to the active site of an enzyme?

Answer 7

• competitive inhibitor

Question 8

Allosteric inhibition involves

Answer 8

• The stabilization of an enzyme in an inactive form

Question 9

In the absence of an inhibitor or activator an enzyme that is allosterically controlled will

Answer 9

• fluctuate between being active and inactive

Question 10

Which of the following statements regarding allosteric regulation is true?

a. The allosteric site of an enzyme can be found within the active site.
b. Allosteric enzymes are often multi-subunit enzymes.
c. Allosteric regulators form polar covalent bonds with the allosteric site.
d. Allosteric enzymes are in their inactive form unless a regulator is present.

Answer 10

• Allosteric enzymes are often multi-subunit enzymes