Alternative Therapies Flashcards Preview

Dental Pharmacology > Alternative Therapies > Flashcards

Flashcards in Alternative Therapies Deck (34):
1

natural coumarin derivatives

anise, celery, chamomile, fenugreek, red clover

2

natural salicylates

meadowsweet, poplar, willowbark

3

antiplatelet action

garlic, ginkgo biloba

4

hypocoagulability- short lived fibrinolytic action

capiscum

5

inhibits 3A4

bitter orange

6

inhibits 1A2 and intestinal 3A4; induces 3A4

echinacea

7

inhibits 1A2 and 2D6

ginkgo biloba

8

inhibits 2D6

ginseng

9

induces 1A2, 3A4, 2C9

St. Johns Wort

10

This list of drugs is impacted by which CYP?:
duloxetine, fluvoxamine, frovatriptan, mexiletine, olanzapine, ropinirole, tacrine, tizanidine and zileuton

1A2

11

This list of drugs is impacted by which CYP?:
amitriptyline, codeine, desipramine, dextromethorphan, metoprolol, oxycodone, tamoxifen, timolol

2D6

12

This list of drugs is impacted by which CYP?:
verapamil, cyclosporine, protease inhibitors, midazolam, simvastatin, atorvastatin, tacrolimus, tamoxifen, triazolam

3A4

13

This list of drugs is impacted by which CYP?:
ARBs, NSAIDs, oral hypoglycemics, warfarin

2C9

14

antagonize immunosuppressants like azathioprine, corticosteroids, cyclosporine, tacrolimus

echinacea and ginseng

15

stimulant effects may oppose sedatives and produce additive actions with epi, phentermine, pseudoephedrine, nicotine or amphetamine

caffeine and green tea

16

contains estrogen-like compounds; long-term use could increase the risk of women developing cancer of the lining of the uterus

red clover

17

increased mean PSA doubling time (effective in treatment of prostatic cancer); CYP3A4 inhibitor; increase rhabdomyolysis with statins

pomegranate juice

18

prevent/treat UTI or H. pylori infections, or prevent dental plaque (antioxidant/anticancer activity); side effects: GI upset or diarrhea

cranberry

19

which vitamins antagonize warfarin?

E and K

20

potent antioxidant (role in maintaining healthy muscle, low serum levels in Parkinsons); hypertension; ischemic heart disease (improvements observed in HDL cholesterol, exercise tolerance); structural similarity with vit. K resulting in possible reduction in warfarin activity

Coenzyme Q10

21

serves as a cartilage nutrient; used for pain associated with knee osteoarthritis; sulfate and hydrochloride forms are available (hydrochloride is ineffective); clinical trials inconclusive

glucosamine

22

serotonin derivative; re-sets body "clock" after jetlag; metabolized by CYP1A2; decrease M/F fertility and breast milk production; interacts with SSRIs and antagonizes effects of antipsychotics

melatonin

23

good evidence of decreasing BPH symptoms w/o shrinking prostate

beta-sitosterols

24

may provide benefit in CV disorders, lower LDL, lower blood sugar, boost immune system and antimicrobial agents and enhance response to flu vaccine

ginseng

25

supplement for mental health: combine with antidepressant; wont work alone

folic acid

26

supplement for mental health: modestly effective in slowing decline---equivalent to AchE inhibitor; additive with AchE inhibitors

ginkgo biloba

27

supplement for mental health: as effective as older TCAs; boost effectiveness of SSRIs

SAMe (s-adenosyl-L-methionine)

28

supplement for mental health: fewer adverse effects than BNZs; useful for sleep/anxiety in children with ANHD

valerian

29

supplement for mental health: boost effectiveness of antidepressants; may trigger mania in bipolar disorder-use with mood stabilizer

omega 3 FA

30

supplement for mental health: works in mild/moderate symptoms of depression; possible alternative medication in children/adolescents

St Johns wort

31

supplement for mental health: improves sleep quality in patient with schizophrenia, major depression and seasonal affective disorder; alternative to drugs in children/elderly

melatonin

32

mineral: enhances insulin action, carb fat and protein metabolism; no proven effects in diabetes, lipid metabolism or body weight/composition; B blockers, corticosteroids, insulin, nicotinic acid and NSAIDs may be enhanced or may increase absorption

chromium (found in broccoli)

33

mineral: important antioxidants preventing free radical damage; cancer: some studies show beneficial effects in prostate, colorectal, lung; HIV: deficiency associated with reduced immune function-may by a significant predictor of survival

selenium (found in brazil nuts)

34

mineral: important cofactor for >300 enzymes, including SOD, involved in protein and carb metabolism; lowers severity of childhood diarrhea in 3rd world; increased healing of gastric ulcers; decreases symptoms of sickle cell anemia

zinc (found in beef, fish, spinach)