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Dental Pharmacology > NSAIDS and DMARDs > Flashcards

NSAIDS and DMARDs Flashcards

(48 cards)

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1
Q

acetylsalisylic acid

A

aspirin

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2
Q

acetaminophen

A

tylenol

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3
Q

celecoxib: only COX2 inhibitor

A

celebrex

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4
Q

COX2 is inducible by …

A

cytokines

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5
Q

NSAIDs do not inhibit …

A

lipoxygenase

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6
Q

protection from cardiovascular disease is additional use of which NSAID

A

aspirin

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7
Q

which drug will close the ductus in neonates when it has remained patent

A

indomethacin

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8
Q

most common side effect of NSAIDs is …

A

gastric or intestinal ulceration

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9
Q

all NSAIDs except … tend to cause GI side effects

A

acetaminophen

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10
Q

aspirin covalently modifies both COX1 and COX2 … … cyclooxygenase activity

A

irreversibly inhibiting

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11
Q

aspirin … COX enzymes

A

acetylates

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12
Q

side effects of which NSAID?: GI ulceration, tinnitus, reyes syndrome

A

aspirin

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13
Q

hepatic toxicity is a major side effect of which NSAID?

A

acetaminophen

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14
Q

therapeutic doses of … do not produce gastric irritation or increase bleeding time

A

acetaminophen

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15
Q

antiinflammatory, analgesic, antipyretic; one of the more potent inhibitors of COX; useful for treatment of arthritis, gout; contraindicated in pregnancy

A

indomethacin

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16
Q

NSAID for postop pain and inflammation; administered intramuscularly or orally; inflammatory conditions in eye

A

ketorolac

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17
Q

potency is greater than indomethacin; non recommended for pregnant women; elevation of hepatic aminotransferase activities in plasma

A

diclofenac

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18
Q

approved as a transdermal NSAID

A

diclofenac

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19
Q

formulation of diclofenac and misoprotol (PGE1 analog) together that provides gastric protection

A

arthrotec

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20
Q

propionic acid derivatives

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A

ibuprofen, naproxen, oxaprozin

21
Q

half life of ibuprofen

22
Q

half life of naproxen

23
Q

half life of oxaprozin

24
Q

equivalent of indomethacin or naproxen; principal advantage is its long half life of 50 hrs

25
more selective COX2 inhibitor although it will inhibit COX1
meloxicam
26
all NSAIDs ... hypotensive effect of antihypertensives
decrease
27
all NSAIDs ... natriuretic and diuretic effects of diuretic agents
decrease
28
all NSAIDs ... anticoagulant effect of oral anticoagulants
increase
29
treatment of all NSAIDs with potassium sparing diuretics, ACE inhibitors, B blockers has potential for
hyperkalemia
30
selective COX2 inhibitor; potential for CV problems
celecoxib
31
very commonly used DMARD; inhibitor of dihydrofolate reductase and interferes with de novo purine biosynthesis; has been used in treatment of various leukemias; treamtent of psoriasis
methotrexate
32
therapeutic effects of methotrexate are within ... weeks
4-6
33
.... supplements are recommended with methotrexate
folic acid
34
methotrexate can by co-administered with ...
glucocorticoids
35
2nd line DMARD; oral pyrimidine synthesis inhibitor; side effect of hepatic toxicity and liver failure
leflunomide
36
antimalarial agent and 2nd live agent used for mild rheumatoid athritis
hydroxychloroquine
37
treats RA, ulcertive colitis, Crohn's; prodrug; colonic bacteria release; 5-aminosalicylic acid-->therapeutic benefit
sulfasalazine
38
elevated ... levels found in synovial fluid of RA patients
TNF
39
major side effect of which class?: increased risk of infections
TNF inhibitors
40
decrease TNFa levels; false receptor; may be used in combo with methotrexate, NSAIDs or other agents (except antibodies directed against cytokines)
etanercept (enbrel)
41
chimeric IgG1 monoclonal antibody; high affinity binding to TNFa; inhibits interaction of TNFa with its receptors
infliximab (remicade)
42
human monoclonal TNFa antibody with human IgG; may be administered with other DMARDs (except biologics) or NSAIDs
adalimumab (humira)
43
TNF human monoclonal antibody; administered as monthly SQ injection
golimumab
44
TNF antibody conjugated to polyethylene glycol; monthly SQ injection
certolizumab
45
interleukin 1 receptor antagonist; one amino acid difference from IL 1; competitively inhibits IL 1
anakinra
46
T cell co stimulatory blocker; CTLA4 binds CD80 on antigen presenting cell and prevents interaction with CD20 on T cell
abatacept
47
depletes B cells; chimeric monoclonal antibody against CD20 on B cell surface
rituximab
48
monoclonal antibody against the IL 6 receptor
tocilzumab

Dental Pharmacology (30 decks)

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