Coagulation Flashcards Preview

Dental Pharmacology > Coagulation > Flashcards

Flashcards in Coagulation Deck (26):
1

intrinsic anticoagulants

protrombin III, protein C, protein S

2

fibrinogen to fibrin is the ... step

last

3

... activation is a critical step and is dependent upon either activation by factor IXa and VIIa or by factor VIIa

factor X

4

... degrades fibrin to fibrin degradation products

plasmin

5

Factors II (prothrombin), V, VII, IX, and X are synthesized in the ...

liver

6

... required for gamma-carboxylation of glutamic acid in factors II, VII, XI, and X

vitamin K

7

... does not require gamma-carboxylation

factor V

8

binds to antithrombin III and increases activity 1K fold

heparin

9

antibodies can form against the complex of ...

heparin-platelet factor 4

10

smaller, active pieces of regular heparin; greater anti-Xa activity, less antiplatelet activity

low molecular weight heparin

11

inhibit thrombin w/o antithrombin III; inhibit thrombin-mediated activation of clotting factors and platelets; action against free and clot-bound thrombin; doesnt induce immune-mediated thrombocytopenia

direct thrombin inhibitors

12

direct thrombin inhibitor; found in salivary glands of the medicinal leech; irreversible binding at active site

hirudin

13

DTIs with reversible binding at active site

bivalirudin, argatroban, melagtran

14

heparin only has action against ... thrombin

free

15

indirect factor X inhibitors

LMW heparins

16

only been approved for DVT; bind to factor X directly and inhibit proteolytic activity to convert prothrombin to thrombin

direct factor Xa inhibitors

17

vitamin K epoxide reductase is required to reduce vit. K at 2 stages, ... binds to the reductase and blocks its activity

warfarin

18

slow onset warfarin is usually administered with another fact acting anticoagulant such as ....

heparin

19

irreversible COX inhibitor that prevents thromboxane formation

aspirin

20

prevents ADP binding and prevents the appearance of GPIIb/IIIa receptors on platelet surface

clopidigrel

21

prevent binding of fibrinogen to platelets

GPIIb/IIIa receptor antagonists

22

agents that increases platelet cAMP ... aggregation

inhibit

23

mimic effects of tissue plasminogen activating factor

thrombolytic agents

24

tissue plasminogen activating factor can only activate when bound to ...

fibrin

25

route of clearance of all thrombolytic agents

liver

26

only thrombolytic agent with indirect fibrin specificity/plasminogen activation

streptokinase