Flashcards in Coagulation Deck (26):
protrombin III, protein C, protein S
fibrinogen to fibrin is the ... step
... activation is a critical step and is dependent upon either activation by factor IXa and VIIa or by factor VIIa
... degrades fibrin to fibrin degradation products
Factors II (prothrombin), V, VII, IX, and X are synthesized in the ...
... required for gamma-carboxylation of glutamic acid in factors II, VII, XI, and X
... does not require gamma-carboxylation
binds to antithrombin III and increases activity 1K fold
antibodies can form against the complex of ...
heparin-platelet factor 4
smaller, active pieces of regular heparin; greater anti-Xa activity, less antiplatelet activity
low molecular weight heparin
inhibit thrombin w/o antithrombin III; inhibit thrombin-mediated activation of clotting factors and platelets; action against free and clot-bound thrombin; doesnt induce immune-mediated thrombocytopenia
direct thrombin inhibitors
direct thrombin inhibitor; found in salivary glands of the medicinal leech; irreversible binding at active site
DTIs with reversible binding at active site
bivalirudin, argatroban, melagtran
heparin only has action against ... thrombin
indirect factor X inhibitors
only been approved for DVT; bind to factor X directly and inhibit proteolytic activity to convert prothrombin to thrombin
direct factor Xa inhibitors
vitamin K epoxide reductase is required to reduce vit. K at 2 stages, ... binds to the reductase and blocks its activity
slow onset warfarin is usually administered with another fact acting anticoagulant such as ....
irreversible COX inhibitor that prevents thromboxane formation
prevents ADP binding and prevents the appearance of GPIIb/IIIa receptors on platelet surface
prevent binding of fibrinogen to platelets
GPIIb/IIIa receptor antagonists
agents that increases platelet cAMP ... aggregation
mimic effects of tissue plasminogen activating factor
tissue plasminogen activating factor can only activate when bound to ...
route of clearance of all thrombolytic agents