Hypolipidemic Agents Flashcards Preview

Dental Pharmacology > Hypolipidemic Agents > Flashcards

Flashcards in Hypolipidemic Agents Deck (31):
1

Condition when blood triacylglycerol or cholesterol in lipoproteins exceeds normal?

Hyperlipoproteinemia

2

Elevated lipoprotein accelerates development of 3 types of atherosclerosis

1. Peripheral vascular disease (thrombosis) 2. Ischemic cerebrovascular disease 3. Coronary heart disease (CHD or myocardial infarction)

3

All of the carbon atoms of Cholesterol are derived from...?

the acetate of Acetyl-CoA

4

Statins inhibits which enzyme of cholesterol synthesis?

HMG-CoA Reductase

5

Dietary lipids are packaged into what in the Exogenous Pathway?

Chylomicrons in the intestinal mucosal cells

6

Fatty acids/cholesterol synthesized in the liver in addition to lipids taken up from blood produce...?

VLDL

7

VLDL deliver lipids to peripheral tissues and become IDL and ...?

LDL

8

Process of HDL bringing cholesterol and cholesterol esters back to the liver?

Reverse Cholesterol Transport

9

What category of drugs is the oldest hypolipidemic drugs?

the "Fibrates"

10

The 1st "fibrate" on the marker?

clofibrate

11

what "fibrate" drugs are useful for lowering VLDL?

gemfibrozil and fenofibrate

12

In the mech of action of "fibrates": what transcription factor is activated to increase fatty acid oxidation and lipoprotein lipase?

PPARa

13

Currently available fibrates?

fenofibrate, fenofibric acid, gemfibrozil

14

1st statin?

lovastatin

15

Progressive muscle side effects of statins?

myalgia, myopathy and rhabdomyolysis

16

Baycol problem?

more aggressive statin therapy = greater side effects

17

Currently available statins?

Atorvastatin (lipitor) and rosuvastatin (preventative therapy)

18

Fish oils that reduce plasma TG and decrease VLDL synthesis?

EPA and DHA

19

FDA approved fish oil?

LOVAZA

20

Recommended dose of Lovaza?

4 grams/day

21

Fish oils do not lower...?

cholesterol

22

Hypolipidemic dose of Niacin is...?

about 3 grams

23

Which B vitamin decreases TAG and increases HDL?

Niacin

24

Mechanism of action of Niacin is to inhibit...?

hormone sensitive lipase

25

Niacin preparations available in US?

Polygel extended release niacin and prescription extended release niacin

26

Mechanism of action of Bile Acid Sequestrants is to...?

block enterohepatic cycling

27

Which class of hypolipidemic agents greatly decreases absorption of negatively charged drugs?

bile acid sequestrants

28

Currently available bile acid sequestrants?

cholestyramine, cholestipol, and cholesevalam

29

Newest class of lipid-lowering agents?

cholesterol absorption inhibitors

30

Mechanism of action of cholesterol absorption inhibitors: inhibits the ... w/o affecting FA uptake?

intestinal cholesterol transporter

31

Example of cholesterol absorption inhibitor?

ezetimbe