Local Anesthetics Flashcards Preview

Dental Pharmacology > Local Anesthetics > Flashcards

Flashcards in Local Anesthetics Deck (29):
1

amide type drugs?

lidocaine, bupivacaine, mepivacaine, prilocaine, ropivacaine

2

ester type drugs?

procaine, chloroprocaine, tetracaine, cocaine

3

amide and ester bonds?

articaine

4

topical use only?

benzocaine, dyclonine, dibucaine, pramoxine

5

compounded projects?

EMLA, LET, phenylephrine-oxymetazoline

6

a reversal agent?

phentolamine

7

antidote to cardiotoxicity?

intralipid

8

ideal qualities of local?

hydrophilic and lipophilic

9

order of sensitivity of nerve fibers?

1. B 2. C (SNS and Dorsal Root) and A delta 3. A gamma 4. A beta 5. A alpha

10

True or False: drug acts proximal to distal

true

11

true or false: recovery gradient runs distal to proximal

false

12

amide drugs have ... metabolism?

hepatic

13

ester drugs have ... metabolism?

non-hepatic

14

symptoms of minor toxicity?

ringing in ears, metallic taste, numbness of lips and tongue (if drug not applied in mouth)

15

Epi interaction possible w/...

B blockers; tricyclic antidepressants (imipramine), halothane, hypertension/heart block, cerebral vascular insufficiency

16

which metabolite of procaine might cause allergic reaction?

PABA

17

which preservatives might cause allergic rxn?

sulphites

18

lipid solubility?

potency

19

dissociation constant?

time of onset

20

chemical linkage?

metabolism

21

protein binding?

duration

22

prilocaine and to a lesser extent benzocaine cause...

methemoglobinemia

23

antidote for methemoglobinemia?

IV methylene blue

24

more potent and cardiotoxic than lidocaine/mepivacaine; prolonged activity; useful for postop analgesia?

bupivacaine

25

reduced cardiotoxicity; greater safety margin?

ropivacaine

26

better penetration into bone; higher incidence of parethesias?

articaine

27

topical for mouth, pharynx, larynx, trachea, esophagus, urethra?

benzocaine and dyclonine

28

topical for skin, not mucosal membranes?

dibucaine and pramoxine

29

which given for suturing?

LET