Antidepressants Flashcards Preview

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Flashcards in Antidepressants Deck (44):
1

First Gen drugs

tricyclics and MAO inhibitors

2

2nd and 3rd Gen drugs

tetracyclics and unicyclics; 5-HT2 antagonists; SSRI; SNRI

3

drugs that inhibit 5-HT reuptake w/ greater potency but not technically SSRIs

trazodone and venlafaxine

4

drug that inhibits NE reuptake w/ greater potency

maprotiline

5

drugs that have little effect on re-uptake of either 5-HT or NE

bupropion and mirtazapine

6

tricyclic dibenzazepine tertiary amine

imipramine

7

tricyclic dibenzazepine secondary amine

desipramine

8

tricyclic dibenzocycloheptadiene tertiary amine

amitriptyline

9

tricyclic dibenzocycloheptadiene secondary amine

protriptyline

10

tricyclic dibenzoxepine tertiary amine

doxepine

11

probably primary action of alleviation of depression of TCAs

blockage of NE reuptake

12

sedative effects of TCAs are enhanced by ...

CNS depressants

13

co-administration of TCAs with ... can lead to sever hyperpyrexia, hypertension, tremors, convulsions, coma or death

MAOIs

14

inhibitors of cytochrome P450 ... will increase concentration of TCAs

erythromycin, clarithromycin, fluoxetine

15

inducer of cyp-450

carbamazepine

16

MAOIs of both MAO A and B

phenelzine and trancylcypromine

17

located in gut and peripheral tissues; preferentially oxidizes 5-HT, but not NE or dopamine

MAO-A

18

located in platelets; preferentially metabolizes dopamine

MAO-B

19

MAOIs block metabolism of ... and other amines found in aged cheese, beer and chianti, may escalate levels of monoamines

L-dopa

20

if MAOIs are given with other anti depressants (esp. SSRIs) may cause ...

malignant serotonin syndrome

21

1st clinically available atypical; tetracyclic; used to treat psychoses and mood disorders; blocks NE greater than 5-HT; sedation and may cause seizures

maprotiline

22

N-demethylated metabolite of antipsychotic drug loxapine; action resembles secondary amine TCAs but also blocks dopamine and 5-HT2a; anticholinergic and parkinsons like side effects

amoxapine

23

triazole derivatives; inhibition of 5-HT2a; weak re uptake inhibition of serotonin and NE; short plasma half life; treatment of depression, insomnia of SSRIs, panic attacks; sedation, CV side effects, priapism of males

trazodone and nefodazone

24

aminoketone; weak inhibitor of NE, 5-HT and DA re-uptake; depression; smoking cessation; seasonal affective disorder; agitation; insomnia, anorexia and weight loss, seizures

bupropion

25

blocks presynaptic A2 receptors; increases amine release by removing feed back inhibition; no effect on serotonin re uptake; CV effects (serious), sedation, dry mouth, blurred vision, weight gain

mirtazapine

26

SSRIs

fluoxetine, sertraline, paroxetine, citalopram, escitalopram

27

half life and daily dose of fluoxetine

70 and 20-80

28

half life and daily dose of sertraline

25 and 50-200

29

half life and daily dose of paroxetine

20 and 10-50

30

half life and daily dose of citalopram/escitalopram

35 and 20-40

31

fluoxetine taken with lithium, TCAs, warfarin

increased action of 2nd drug

32

fluvoxamine taken with alprazolam, theophylline, TCAs and warfarin

increased blood levels of 2nd drug

33

MAOIs taken with SSRIs, food containing tyramine

hypertensive crisis, serotonin syndrome

34

nefazodone taken with alprazolam, triazolam

increased blood levels of 2nd drug

35

paroxetine, sertraline taken with warfarin, TCAs

increased blood levels of 2nd drug

36

TCAs taken with sedative/hypnotics, ethanol

increased CNS depression

37

highly sedating

amitriptyline, doxepin, trazadone, mirtazapine

38

anti muscarinic effects

amitriptyline and doxepin

39

SSRIs generally lack ... and are safe in overdose

sedating activities

40

main line drug of bipolar disorder

lithium salts

41

diabetes insipidus

chronic toxicity of lithium salts

42

plasma levels of lithium are elevated by

thiazide diuretics (chlorothiazide) and ACE inhibitors (catopril)

43

NSAIDs decrease ...

renal excretion

44

alcohol and caffeine promote ...

lithium excretion