Psychotic drugs and abuse Flashcards Preview

Dental Pharmacology > Psychotic drugs and abuse > Flashcards

Flashcards in Psychotic drugs and abuse Deck (32):
1

CNS stimulants

methylxanthine derivatives (caffeine, theophylline), nicotine, amphetamine related drugs

2

amphetamine related drugs

amphetamine, phentermine, methamphetamine, phenfluramine, methylphenidate, cocaine

3

CNS depressants

opioids, marijuana, ethanol, barbiturates/benzodiazepines

4

other psychoactive drugs and hallucinogens

LSD, mescaline, PCP

5

caffeine blocks ... receptors which increased dopamine transmission

adenosine

6

caffeine inhibits ... resulting in increased cAMP; mobilizes intracellular Ca

phosphodiesterase

7

caffeine has ... ionotropic and chronotropic effects at high doses (both harmful in some heart conditions)

positive

8

activates cholinergic-nicotinic receptors in CNS and periphery, euphoria, arousal, improved memory and concentration, appetite suppression, inhibits MAO, highly addictive

nicotine

9

nicotine ... vessels; neg. effects on blood vessels

constricts

10

drugs of choice for ADHD

amphetamine; methylphenidate

11

used in weight reduction

phentermine; fenfluramine; diethylpropion; phendimetrazine

12

treatment for narcolepsy

D-amphetamine and methylphenidate

13

potent local anesthetic; vasoconstriction; powerful psychostimulant; dependence; activates sympathetic; increased alertness/motor activity; tachycardia/hypertension; pupillary dilation; potent dopamine agonist; euphoria; increased sex drive

cocaine

14

direct activation of the endogenous reward system (dopamine); micro-strokes; withdrawal from depletion of NE and DA

cocaine

15

most commonly abused opioids by general population

heroin; oxycodone; morphine

16

most commonly abused opioid by health professionals

meperidine and fentanyl

17

meperidine induces ... pupils in tolerant individuals

dilated

18

opioid overdose reversal

naloxone

19

opioid dependence maintenance therapy

methadone

20

THC

marijuana

21

the endogenous ligand of cannabinoid receptor located in cerebellum, hippocampus and basal ganglia

anandomide

22

anticholinergic-hallucinogenic drug of abuse

scopolamine (night shade plant)

23

catecholamine like-hallucinogenic drugs of abuse

MDMA (ecstasy) and mescaline (Peyote)

24

serotonin like-hallucinogenic drugs of abuse

LSD and psilocybin (mushroom)

25

glutaminergic NMDA antagonists (hallucinogenic drugs of abuse)

PCP and ketamine

26

pharmacologic treatment of amphetamine intoxication

lorazepam for agitation and haloperidol for psychosis

27

pharmacologic treatment for BZDs

flumazenil

28

pharmacologic treatment for cocaine

lorazepam for agitation or seizures

29

pharmacologic treatment for hallucinogens

lorazepam for agitation

30

pharmacologic treatment for marijuana

lorazepam for agitation

31

pharmacologic treatment for opioids

naloxone

32

pharmacologic treatment for PCP

lorazepam for agitation and haloperidol for psychosis