Flashcards in Autonomics lecture 1 Deck (50):
The autonomic nervous system is comprised of 2 neurons in a chain, what are they?
In you ganglion what are all the ACh receptors?
What type of receptor do you find in the sympathetic portion of sweat glands?
Pre ganglionic cell bodies in the sympathetic nervous system are ______?
Where do axons from the sympathetic nervous system extend to?
-pre and para vertebral ganglia (tend to be short)
Where do you find post ganglionic cell bodies?
-Para and pre vertebral ganglia
Where to post ganglionic axons extend to?
Sympathetic pre-ganglionic also innervate adrenal medulla causing the adrenals cells to release what into the bloodstream?
-Norepinephrine and epinephrine
In parasympathetic nervous systems the pre-ganglionic cell bodies are what?
Where do pre-ganglionic axons extend to?
-Ganglia located near or in effector tissues/organs
What neurotransmitter is used by both the sympathetic and parasympathetic pre-ganglionic fibers?
ACh acts through what receptors located on post- ganglionic fibers?
T/F Drugs that alter ACh levels affect both the sympathetic and parasympathetic systems
Motor neurons innervating skeletal muscle also cat via what receptors?
What do post ganglionic sympathetic use for neurotransmitters?
What does DA activate?
Post ganglionic parasympathetic use what for a neurotransmitter?
What does ACh act on in post ganglionic effector tissues and somatic muscles?
--Muscarinic in effector
-Nicotinic in somatic muscles
Where do you find M1 receptors?
What is the agonist for M1, M2, and M3 receptors?
What is the response from an M1 receptor?
-Increase acid secretion
What are the antagonists for M1, M2, and M3 receptors?
What do M2 receptors act on?
What are the responses from M2 receptors?
-Decrease AP duration and contractility
-Decrease conduction velocity
What does M3 act on?
-GI smooth muscle
What are the responses for M3 receptors?
What are the receptors for the parasympahetic nervous system?
What is the agonist for Nm and Nn receptors?
What is the antagonist for Nm?
What is the antagonist for Nn?
What tissues do Nm receptors act on?
What tissues do Nn receptors act on?
What are the two classes of nueromuscular blockers?
What does Tubocurare do?
-Competes with ACh at nicotinic receptors
What does succinylcholine do?
-Act as a nicotinic agonist and depolarizes/desensitizes the neuromuscular endplate making the neuron unresponsive to another ACh challenge
What does a block of AChE do?
-Affect both parasympathetic and sympathetic systems
-Affects tissues innervated by post-ganglionic fibers
-Affects signaling at the neuromuscular junction
If you have an increase in ACh what happens to you heart?
What is Sarin?
-A cholinesterase inhibitor (causes an increase in ACh)
What does an increase in ACh do to salivation?
What does and increase in ACh do to eyes?
-Makes them watery
-blurred vision (dilated pupils)
What does an increase in ACh do to sweating?
What does an increase in ACh do to the GI?
-Give you diarrhea
What is a cholinesterase inhibitor that has a short duration of action and is used for glaucoma, and is an antidote for atropine?
What does physostigmine do?
-It is a short duration
-Used for glaucoma
-Antidote for atropine
What is Donepezil (aricept)?
What does Donepezil (aricept) to?
-Extended duration of actions
-Used to treat Alzheimer's
What does Botulinim toxin do?
-Prevents release of ACh
-Relax intraocular muscles
-Treats muscle dystonia (spasms)
What are cholinergic agents used in dentistry?
What is Cevimeline used for?
-Treat xerostomia in Sjogren's syndrome