Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Human disease and therapeutics 2020 > Test #3 Antiinflammatory drugs/ anti-acne drugs/ muscle relaxants > Flashcards

Test #3 Antiinflammatory drugs/ anti-acne drugs/ muscle relaxants Flashcards

(54 cards)

Start Studying
1
Q

What is the goal of NSAIDS?

A

-Decrease Pain and inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the side effects of COX I inhibitors?

A
  • GI
  • Bleeding
  • Kidney side effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the side effects of COX II inhibitors?

A
  • MI
  • Stroke
  • Hypertension
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are non-selective COX I and II inhibitor drugs?

A
  • Aspirin
  • Ibuprofen
  • Naproxen
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is a selective COX II inhibitor?

A

-Celecoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are adverse effects common for all NSAIDS?

A

Tinnitis (CNS) and skin rashes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are CVS adverse effects of NSAIDs?

A

-Hypertension (COX-II)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are GI adverse effects of NSAIDS?

A
  • Nausea
  • Ulcers
  • Bleeding
  • COX-I
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are Hepatic adverse effects of NSAIDS

A

-Altered liver functions (COX-I)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are Pulmonary adverse effects of NSAIDS?

A

-Asthma (COX-I)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are skin adverse effects of NSAIDS?

A

-Rashes (all NSAIDs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are Renal adverse effects of NSAIDS?

A
  • Insufficiency (COX-I and II)

- can have renal failure in extreme cases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Glucocorticoids have a dramatic effect on what?

A

-Inflammation and slowing bone erosions in RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the side effects of glucocorticoids? how can you minimize the side effects?

A
  • Loss of muscle mass
  • Osteoporosis
  • Diabetogenesis
  • Peptic ulcers
  • Round face
  • Buffalo hump
  • minimize side effects by applying close to site of inflammation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is a long acting glucocorticoids?

A

-Dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are short to medium acting glucocorticoids?

A
  • Cortisone

- Prednisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are some examples of DMARDS drugs?

A
  • Methotrexate

- Sulfasalazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What do DMARDS do?

A

-Decrease inflammation and slow bone damage in RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is Entanercept?

A
  • Anti-rhumatic/anti-autoimmune disease

- It inhibits inflammation by blocking TNF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is Infliximab?

A
  • Antibody that blocks TNF

- used to treat inflammatory diseases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the cause of acne vulgaris?

A

-Inflammation/bacterial infection of plugged sebaceous glands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What do topical keratolytics do?

Study These Flashcards
A
  • Treat acne vulgaris

- Remove keratin layer and opens sebaceous glands (also used as wart removers)

23
Q

What are two topical keratolytics?

Study These Flashcards
A
  • Salicylic acid

- Benzoyl peroxide

24
Q

What are antibiotics used to treat acne vulgaris?

Study These Flashcards
A
  • Erythromycin
  • Tetracycline
  • Clindamycin
  • Metronidazole
  • Dapsone
25
What are Retinoids?
-Vitamin A derivatives
26
What is a topical Retinoid?
-Retin A (Tretinoin)
27
What is a systemic Retinoid?
-Isotretinoin (Accutane)
28
What are the side effects of Retinoids?
- Dry skin - Sores - Major birth defects with isotretinoin
29
What are non-drug treatments to control acne vulgaris?
- UV phototherapy (acne causing bacteria are UV sensitive) | - Diet therapy
30
Muscle relaxants enhance levels of inhibition usually via what pathway?
-CNS (GABA mediated)
31
What type of muscle relaxants reduce muscle stretch reflex?
-Antispasmotics
32
What are five antispasmotic drugs?
- Diazepam - Baclofen - Dantrolene - Carisoprodol - Tizanidine
33
What is Baclofen?
- GABA b agonist | - Antispasmotic
34
What is Dantrolene?
- Alters Ca 2+ trafficking | - Antispasmotic
35
What drug used as an antispasmotic, works at the soma, and may have some dependence problems?
-Carisoprodol
36
What is a non-depolarizing neuromuscular blocking drug?
- D-Tubocurarine | - Pancuronium
37
What does D-Tubocurarine do?
-Block ganglionic nicotinic receptor
38
Acetylcholinesterase inhibitors block by overwhelming the blockade with what?
-ACh
39
What is a depolarizing neuromuscular blocking?
-Succinylcholine
40
How does succinylcholine block ganglionic nicotinic receptors?
-By desensitizing (overstimulating)
41
Does an acetylcholinesterase inhibitor reverse succinylcholine?
No
42
What are some viral thymidine kinase-dependent types of drugs used to treat singles and herpes?
- Acyclovir | - Famicyclovir
43
What is Zovirax or Denavir?
-Acyclovir drugs (ointments)
44
What drug is most effective for HSV 1 and 2 but is less potent on VZV?
-Acyclovir
45
What drug is effective against VZV and herpes viruses and is longer acting than acyclovir?
-Famicyclovir
46
What are some non-thymidine kinase dependent antiviral drugs?
- Foscarnet | - less of a resistant problem than thymidine kinase-dependent types
47
What are topical drugs used for cold sores/recurrent HSV?
- Denavir cream (Penicyclovir) - Zovirax - both are acyclovirs
48
what can chronic inflammation lead to?
- cancers - pulmonary disease - cardiovascular disease - diabetes - alzheimers disease - oral diseases (periodontal tissues) - neurological diseases - arthritis
49
how do glucocorticoids work?
block upstream mediators of inflammatory cascade by inhibiting phospholipases
50
what are the uses of glucocorticoids?
- allergic reactions - GI diseases (inflammatory bowel disease) - infections (sepsis) - joint inflammation (RA) - skin diseases (dermatitis) - pulmonary (asthma)
51
how are DMARDs potentially more toxic than other options?
- severe hepatotoxicity - stomatitis - immunosuppression
52
how do retinoids work to treat acne?
- increase exfoliation and clears follicles | - reduces sebum production and opens follicles
53
what are D-tubocurarine and pancuronium blocked by?
acetylcholinesterase inhibitors
54
how can you get the best effects of antiviral use for shingles and herpes?
use early in infection

Human disease and therapeutics 2020 (60 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions