Flashcards in Pain lecture 3 Deck (23):
Nociceptive pain is normally terminated by what?
-Healing and repair process
Where do you find the periacqueductal gray?
What are the endogenous opioid peptides known as?
What are the basic endorphins?
-Methionine and leucine known as enkephalins
What receptors do enkephalins work on?
-Mu and delta
What are most opioid drugs?
Mu opioid agonists
How many amino acids do you find in enkephalins?
Beta endorphins are made of how many amino acids?
What do endorphins do?
-Increase dopamine release in our reward pathway
Dynorphins A and B react with with opioid receptor?
-Kappa with slight mu and delta interactions
How many amino acids make up dynoprhins?
Do Dynorphins have addiction potential?
What are dynorphins a big regulator of?
Drugs that enhance the action of NE and 5HT have what type of effects?
Opioid analgesics act in what places?
Periacqueductal gray and dorsal horn
In the dorsal horn these Endogenous pain suppressants do what?
-Inhibit the release of pain transmitters
What are neuropathic pain features?
-Pain sensations may be continuous or periodic but occur without activation of nociceptors
-1 or multiple peripheral nerves caused by damage to the nerves
What can cause neuropathic pain?
-Abnormal activity in nociceptive fibers
-Abnormal activity in central pain pathways
What are some examples of neuropathic pain?
Do neuropathic pain treatments respond to NSAIDs?
T/F Neuropathic pain treatment response inconsistently to opioids
Besides Opioids some people with neuropathic pain can respond to what other drugs?
-Anticonvulsants (Lyrica, Gabapentin)