Pain lecture 3 Flashcards Preview

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Flashcards in Pain lecture 3 Deck (23):
1

Nociceptive pain is normally terminated by what?

-Healing and repair process

2

Where do you find the periacqueductal gray?

-Midbrain

3

What are the endogenous opioid peptides known as?

-Endorphins

4

What are the basic endorphins?

-Methionine and leucine known as enkephalins

5

What receptors do enkephalins work on?

-Mu and delta

6

What are most opioid drugs?

Mu opioid agonists

7

How many amino acids do you find in enkephalins?

5

8

Beta endorphins are made of how many amino acids?

-91

9

What do endorphins do?

-Increase dopamine release in our reward pathway

10

Dynorphins A and B react with with opioid receptor?

-Kappa with slight mu and delta interactions

11

How many amino acids make up dynoprhins?

-17

12

Do Dynorphins have addiction potential?

-No

13

What are dynorphins a big regulator of?

-Dopamine

14

Drugs that enhance the action of NE and 5HT have what type of effects?

-Anti nociceptive

15

Opioid analgesics act in what places?

Periacqueductal gray and dorsal horn

16

In the dorsal horn these Endogenous pain suppressants do what?

-Inhibit the release of pain transmitters

17

What are neuropathic pain features?

-Pain sensations may be continuous or periodic but occur without activation of nociceptors
-1 or multiple peripheral nerves caused by damage to the nerves

18

What can cause neuropathic pain?

-Abnormal activity in nociceptive fibers
-Abnormal activity in central pain pathways

19

What are some examples of neuropathic pain?

-Phantom limb
-Diabetes neuropathies
-Shingles
-Trigeminal neuralgia
-Fibromyalgia

20

Do neuropathic pain treatments respond to NSAIDs?

-No

21

T/F Neuropathic pain treatment response inconsistently to opioids

True

22

Besides Opioids some people with neuropathic pain can respond to what other drugs?

-Antidepressants (Cymbalta)
-Anticonvulsants (Lyrica, Gabapentin)
-Corticosteroids

23

What are some possible mechanisms of neuropathic pain?

-Peripheral sensitization process may persist rather than subside
-Damaged nociceptive nerves may fire spontaneously
-Prolonged input from hyperexcitable nociceptive fibers
-Decreased activity of endogenous pain suppressant neural system

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