Flashcards in Autonomics lecture 3 Deck (65):
Why can peripheral resistance decrease when you give epinephrine slowly and a low amount?
Why can peripheral resistance increase when you give epinephrine fast and a high amount?
-Alpha 1 receptors
What does the heart rate go up when you give epinphrine?
-Beta 1 receptors
If you give epinephrine slowly and a low amount how can your diastolic pressure go down?
-Because of the decrease in peripheral resistance
What receptors do you find for norepinephrine?
What beta receptor does norepinephrine have a higher affinity for?
What does norepinephrine do to the peripheral resistance?
-Increase peripheral resistance
If a person got norpinephrine can a person have a slower HR and why?
-Yes because the override beta 1 receptors
What receptors can Dopamine use?
What dopamine receptors increase BP and TPR?
What dopamine receptors increase HR?
What dopamine receptors increase organ perfusion?
What are alpha 1 agonists?
What are the effects of Alpha 1 agonists?
-Vasoconstriction and increased TPR
-Decreased HR (but can increase because of Baroreceptors)
-Constricts sphincter muscle of bladder
What are alpha 2 agonists?
What are the effects of Alpha 2 agonists?
-Bradycardia in some
What does stimulation of CNS alpha 2 receptors decrease?
What are alpha 2 agonists used for?
-Treatment of hypertension
What are alpha 1 agonists used for?
-Mydriasis (pupil dilation)
What are the uses for Beta agonists?
-OBGYN use to relax smooth muscle of uterus during labor slowing contractions
What are mixed agonists?
What do the mixed agonists release?
What can amphetamine cause the release of?
-NE and DA
What are indirect adrenergic agents?
What does cocaine do for the indirect action?
-Blocks the uptake of excess NE, DA, and Serotonin
What does Methylphenidate do?
-Block reuptake of NE and DA
What metabolizes Tyramine?
If a person is taking a Monoamine oxidase inhibitor what should a person avoid?
-Foods that contain Tyramine
What can increase Tyramine do?
-Increase the amount of Norepinephrine release
Is tyramine and indirect agonist?
What are examples of non-selective alpha antagonists?
What do you use non-selective alpha antagonists for?
What are the effects of non-selective alpha antagonists?
-Decreased TPR (alpha 1) and thus decreased BP
-Increased HR (Baroreceptor response to decreased BP)
What are alpha 1 antagonists?
What are the effects of alpha 1 antagonists?
-Vasodilation (not really because they just stop vasoconstriction) causes a decrease in TPR and BP
What are the uses of alpha 1 antagonists?
-Benign Prostatic hypertrophy
What are the examples of Beta Antagonists (beta blockers)?
-Propranolol (B1 and B2)
What is the uses of beta blockers?
-Treatment of hypertension
-Treatment of angina
What is the metabolic effect of beta blockers?
-Decreased glycogenolysis in response to hypoglycemia
What is the effect of sympathetic activity when the B2 and alpha receptors are activated for metabolic function?
Scopolamine is an antagonist at this receptor?
Atropine is an antagonist at this receptor?
Succinylcholine is an antagonist at this receptor?
Phenylephrine is a what?
-Alpha 1 agonist
D tubocurarine is an antagonist at this receptor?
Atropine can cause what?
-Decreased Heart rate
Which receptors regulate renin secretion?
Drugs classified as alpha-blockers can help decrease what?
What receptors are involved in gluconeogenesis?
What receptors are involved in glycogenolysis?
What receptors do you find in the SA node?
What receptors do you find in skeletal muscle vessels?
What receptors do you find in skin, splanchnic vessels?
Apocrine and eccrine gland are regulated by what receptors respectively?
-Alpha then muscarinic
What can decrease aqueous humor production?
What receptors act on the bladder wall?
What receptors act on the sphincter?
What receptors act on the uterus?
What receptors are responsible for contracting the uterus?
What receptors are found in the penis/seminal vesicles?
What does the Beta 2 receptor do in skeletal muscle vessels?
Is there any parasympathetic activity that controls metabolic function?
-No it is all done via the sympathetic activity
Is there any parasympathetic activity that control the blood vessels?
What receptors control the radial muscle?