Autonomics lecture 3 Flashcards Preview

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Flashcards in Autonomics lecture 3 Deck (65):
1

Why can peripheral resistance decrease when you give epinephrine slowly and a low amount?

-Beta 2

2

Why can peripheral resistance increase when you give epinephrine fast and a high amount?

-Alpha 1 receptors

3

What does the heart rate go up when you give epinphrine?

-Beta 1 receptors

4

If you give epinephrine slowly and a low amount how can your diastolic pressure go down?

-Because of the decrease in peripheral resistance

5

What receptors do you find for norepinephrine?

Alpha
Beta

6

What beta receptor does norepinephrine have a higher affinity for?

-Beta 1

7

What does norepinephrine do to the peripheral resistance?

-Increase peripheral resistance

8

If a person got norpinephrine can a person have a slower HR and why?

-Yes because the override beta 1 receptors

9

What receptors can Dopamine use?

-DA
-Beta
-Alpha

10

What dopamine receptors increase BP and TPR?

-Alpha 1

11

What dopamine receptors increase HR?

Beta 1

12

What dopamine receptors increase organ perfusion?

-D1

13

What are alpha 1 agonists?

-Phenylephrine
-Methoxamine

14

What are the effects of Alpha 1 agonists?

-Vasoconstriction and increased TPR
-Decreased HR (but can increase because of Baroreceptors)
-Constricts sphincter muscle of bladder

15

What are alpha 2 agonists?

-Clonidine
-Guanfacine

16

What are the effects of Alpha 2 agonists?

-Bradycardia in some
-Dry mouth

17

What does stimulation of CNS alpha 2 receptors decrease?

-Sympathetic output

18

What are alpha 2 agonists used for?

-Treatment of hypertension
-ADHD

19

What are alpha 1 agonists used for?

-ENT surgery
-Treat hypotension/shock
-Mydriasis (pupil dilation)
-Nasal decongestants

20

What are the uses for Beta agonists?

-Asthma
-COPD
-OBGYN use to relax smooth muscle of uterus during labor slowing contractions
-Bronchospasm

21

What are mixed agonists?

-Ephedrine
-Ephedra
-Pseudoephedrine

22

What do the mixed agonists release?

-Norepinephrine

23

What can amphetamine cause the release of?

-NE and DA

24

What are indirect adrenergic agents?

-Amphetamine
-Cocaine
-Methylphenidate
-NNRIs
-TCA

25

What does cocaine do for the indirect action?

-Blocks the uptake of excess NE, DA, and Serotonin

26

What does Methylphenidate do?

-Block reuptake of NE and DA

27

What metabolizes Tyramine?

-Monoamine oxidase

28

If a person is taking a Monoamine oxidase inhibitor what should a person avoid?

-Foods that contain Tyramine

29

What can increase Tyramine do?

-Increase the amount of Norepinephrine release

30

Is tyramine and indirect agonist?

Yes

31

What are examples of non-selective alpha antagonists?

-Phenoxybenzamine
-Phentolamine

32

What do you use non-selective alpha antagonists for?

-Treat pheochromocytoma
-Hypertensive emergencies

33

What are the effects of non-selective alpha antagonists?

-Decreased TPR (alpha 1) and thus decreased BP
-Increased HR (Baroreceptor response to decreased BP)

34

What are alpha 1 antagonists?

-Prazosin
-Terazosin

35

What are the effects of alpha 1 antagonists?

-Vasodilation (not really because they just stop vasoconstriction) causes a decrease in TPR and BP

36

What are the uses of alpha 1 antagonists?

-Treat hypertension
-Benign Prostatic hypertrophy

37

What are the examples of Beta Antagonists (beta blockers)?

-Propranolol (B1 and B2)
-Atenolol (B1)
-Metoprolol (B1)

38

What is the uses of beta blockers?

-Treatment of hypertension
-Treatment of angina

39

What is the metabolic effect of beta blockers?

-Decreased glycogenolysis in response to hypoglycemia

40

What is the effect of sympathetic activity when the B2 and alpha receptors are activated for metabolic function?

-Gluconeogenesis
-Glycogenolysis
-Lipolysis
-Renin release

41

Scopolamine is an antagonist at this receptor?

-Muscaranic

42

Atropine is an antagonist at this receptor?

-Muscaranic

43

Succinylcholine is an antagonist at this receptor?

-Nicontinic muscle

44

Phenylephrine is a what?

-Alpha 1 agonist

45

D tubocurarine is an antagonist at this receptor?

-Nicotinic Muscle

46

Atropine can cause what?

-Dilated pupils
-Dry mouth
-Decreased Heart rate

47

Which receptors regulate renin secretion?

-Beta 1

48

Drugs classified as alpha-blockers can help decrease what?

-Blood pressure

49

What receptors are involved in gluconeogenesis?

-Beta 2
-Alpha

50

What receptors are involved in glycogenolysis?

-Beta 2
-Alpha

51

What receptors do you find in the SA node?

-Beta 1
-Beta 2
-Muscarinic

52

What receptors do you find in skeletal muscle vessels?

-Beta 2

53

What receptors do you find in skin, splanchnic vessels?

-Alpha

54

Apocrine and eccrine gland are regulated by what receptors respectively?

-Alpha then muscarinic

55

What can decrease aqueous humor production?

-Clonidine

56

What receptors act on the bladder wall?

-Beta 2
-Muscarinic

57

What receptors act on the sphincter?

-Alpha 1
-Muscarinic

58

What receptors act on the uterus?

-Beta 2
-Alpha
-Muscarinic

59

What receptors are responsible for contracting the uterus?

-Alpha
-Muscarinic

60

What receptors are found in the penis/seminal vesicles?

-Alpha
-Muscarinic

61

What does the Beta 2 receptor do in skeletal muscle vessels?

-Relaxes

62

Is there any parasympathetic activity that controls metabolic function?

-No it is all done via the sympathetic activity

63

Is there any parasympathetic activity that control the blood vessels?

-No

64

What receptors control the radial muscle?

-Alpha 1

65

If the radial muscle contracts what does that do to the pupil?

-Dilate

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