Pain treatment lecture 2 Flashcards Preview

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Flashcards in Pain treatment lecture 2 Deck (40):
1

What do Ibuprofen type NSAIDs do?

-COX 1 and COX 2 inhibitor

2

What amount of Ibuprofen is needed for an analgesic effect?

-400 mg

3

What amount of ibuprofen is needed for anti-inflammation?

-800 mg

4

What type of pain do you use ibuprofen for?

-Mild to moderate pain relief

5

What are the side effects of ibuprofen type NSAIDs?

-GI ulcers
-Anti-clotting
-Cardiovascular effects

6

What amount of ibuprofen is needed for antipyretic action?

-400 mg

7

What type of people should you be cautious in giving ibuprofen?

-Heart disease
-High blood pressure
-Diabetes
-Strokes

8

What are some special properties of ibuprofen like NSAIDs?

-Ketoprofen (Orudis)
-Naproxen (Naprosyn)

9

How does ketoprofen compare to ibuprofen?

-More potent at lower doses

10

How does Naproxen (alleve) compare to Ibuprofen?

-Longer lasting and slower acting

11

Why would you use Celecoxib?

-Lacks GI and anti-clotting action because it is a COX-2 selective antagonist

12

T/F Celecoxib has been linked with cardiovascular side effects

True

13

What are some other NSAID agents? (these are used in arthritis)

-Indomethacin
-Meloxicam
-Diflunisal (Dolobid)

14

What is Indomethacin?

-Potent non-selective NSAID/due to side effects not a common analgesic

15

What is Meloxicam?

- Preferentially inhibits COX-2 over COX-1 which means less GI problems

16

What is Diflunisal (Dolobid)?

-Related to salicylates and is supposed to be good for bone pain

17

What are the possible mechanisms of Acetaminophen?

-Inhibits a COX3 enzyme or serotonin

18

What are the side effects of acetaminophen?

-Liver toxin in high doses
-Pts with compromised livers should not use

19

What are the analgesic uses of NSAIDs?

-Somatic pain
-Mild to moderate pain

20

What type of somatic pain could you use NSAIDs for?

-Most dental pain
-Most headaches (Tension and congestion types not migraines)
-Most muscle and joint pains
-Most earaches

21

What are some NSAID contraindications?

-Pt on anticoagulants
-Hemophiliac
-Ulcers
-Already taking high doses
-Child or adolescent
-History of allergies

22

What are some anticoagulants?

-Coumadin (Warfarin)/ Pradaxa
-Joint replacement
-Heart attack/ stroke
-Major surgery
-Atrial fibrillation

23

What are some signs of a possible ulcer?

-Frequent upset stomach
-Bleeding in stool
-Take antacids
-Takes H2 blockers (tagamet)

24

What are the therapeutic uses of opioid narcotics?

-Analgesia
-Somatic and visceral pain
-Mild to severe
-Antitussive (blocks the coughing center)
-Antidiarrheal

25

What are six of the most commonly used narcotics?

-Morphine
-Hydromorphone
-Oxymorphone
-Oxycodone
-Hydrocodone
-Codeine

26

What are the more potent forms of narcotics?

-Morphine/morphones

27

What is a less potent narcotic?

-Codeine/Codone

28

Are hydros or oxys more potent?

-Oxy

29

What type of narcotics are lortab and vicodin?

-Hydrocodone + acetaminophen

30

What is Meperidine (Demerol)?

-Narcotic analgesic for moderate pain

31

What is Pentazocine (Talwin)?

-A Narcotic analgesic that is a Mixed agonist/antagonist that treats moderate pain

32

What is methadone?

-Narcotic analgesic for moderate to strong pain that is used to treat opioid addiction and as an analgesic

33

What is Buprenorphine?

-Narcotic analgesic for moderate analgesic mixed agonist and antagonist that is used to treat opioid addiction

34

What is one of the most potent narcotics?

-Fentanyl .1 mg

35

What are the major opioid agonist side effects?

-Respiratory depression
-Decreased pulmonary reflex
-Constipation/slow bowel movement
-Sedation/additive or synergistic with other CNS depressants
-Euphoria/dependence/addiction

36

What is the treatment for opioid overdose?

-Inject naloxone (Narcan)

37

What type of drug is Oxycontin/Percodan?

-Oxycodone

38

What are contraindications for opioids?

-History of substance abuse
-Sever constipation or upset stomach
-Respiratory problems
-CNS depressants
-Allergies

39

When managing neuropathic pain what is the first line treatment drugs?

-Gabapentin
-Duloxetine
-Nortriptyline

40

What is the next line of treatment of managing neuropathic pain?

-Tramadol

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