Flashcards in Biological Interventions - Addiction Deck (13):
What are some forms of nicotine replacement therapy?
Gum, patches, tablets, spray etc
How do NRTs such as patches provide negative reinforcement?
Release nicotine through your waking hours
- background level of nicotine is thought to desensitise the nicotine receptors in the brain
= get less of a response from smoking - provides no 'high' just calms withdrawal symptoms
How can NRTs sometimes provide positive reinforcement?
Some such as sprays deliver effects similar to the mill 'high of a cigarette - instant hit of nicotine
What are some general advantages of NRT?
- Much healthier than smoking even if someone is on it for a long period of time
- All the change in the delivery system for NRT have increased their effectiveness
What are some general weaknesses of NRT?
- Can work really well with help but people often misuse it individually with no advice
= wrong level of nicotine, only use one product etc
What did Tang et al do?
Meta-analysis of 28 randomised trials of nicotine 2mg gum, 6 of nicotine 4mg + 6 of a nicotine patch
- participants were self-referred in 20 trials and invited in 20
What did Tang et al find?
Defined efficacy as = the difference in percentage of treated and control subjects who had stopped smoking in one year
- Efficacy was highly significant (P=0.001) for both gum and patch§
What is Bupropion?
An anti-depressant drug which increases dopamine and noradrenaline in the brain
How is Bupropion thought to help give up smoking?
Thought to reduce the amount of nicotine receptors in the brain making the person less likely to crave a cigarette
What did Jorenby et al do?
Treatment that consisted of nine weeks of bupropion or placebo, as well as eight weeks of nicotine-patch therapy or a placebo
What did Jorenby et al find?
Abstinence rates at 12 months:
- 15% for placebo group
- 16% for patch group
- 30% for bupropion group (P=0,001)
- 35% for bupropion + patch group (P=0.001)
= combining therapies is the most effective
What is a weakness of Bupropion?
Has horrible side effects such as nightmares