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Flashcards in Dermatologic Diseases Deck (57)
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_ _ form of epidermolysis bullosa: much more serious; secondary infections; mitten deformity; microstomia; dental caries

recessive dystrophic


epidermolysis bullosa: _ (intraepithelial clefting)



epidermolysis bullosa: _ and _ ( subepithelial clefting (lamina lucida or lamina densa))

junctional and dystrophic


autoimmune disorder characterized by antibodies directed against components of the epithelial desmosome complex; oral signs are often the first manifestations of the disease and the most difficult to resolve

pemphigus vulgaris


>50% present with oral lesions; ragged erosions and ulcerations; any oral mucosal surface; flaccid bullae on skin; oral blisters rarely seen; Nikolsky's sign



Serious vesiculobullous disorder affecting patients with neoplastic disease, typically a lymphoreticular malignancy (CLL and lymphoma); antibodies in response to the tumor probably cross react with components of the epithelial layer; cytotoxic T lymphocytes may also play a role in cutaneous and mucosal damage

paraneoplastic pemphigus


clinically resembles a number of conditions: erythema multiforme, pemphigus, lichen planus, pemphigoid; oral lesions: hemorrhagic crusting of lips, diffuse ulcerations

paraneoplastic pemphigus


lichenoid mucositis with subepithelial clefting; direct immunofluorescence- C3 and IgG granular/linear at BMZ or intercellular; indirect immunofluorescence- serum antibodies reactive to intercellular area of rat bladder epithelium; immunoprecipitation

paraneoplastic pemphigus


group of autoimmune disease characterized by autoantibodies directed against one or more components of the basement membrane; clinically resembles pemphigus due to blister formation; about 2x more common than pempigus

cicatricial pemphigoid


F>M, avg age 60; desquamative gingivitis; may see intact blisters intraorally; affects any mucosal surface, occasionally skin; scarring usually refers to conjunctival mucosa (symblepharon); entropian, trichiasis

cicatricial pemphigoid


similar autoimmune condition to cicatricial pemphigoid, with a few distinct differences; positive DIF and indirect IF- BMZ; often resolves in 2-5 years; healing occurs without scarring; more likely to involve skin than oral mucosa

bullous pemphigoid


M=F, 60-80 years; early pruritis may be an early symptom; skin- tense bullae which rupture, crust, and heal without scarring; oral - rare, bullae which rupture quickly

bullous pemphigoid


acute, self-limiting ulcerative disorder; probably immune-mediated; 50%- unknown; 25%-drugs (particularly antibiotics or analgesics); 25%- infection (herpes/Mycoplasma)

erythema multiforme


M>F; young adults; may experience prodrome; hemorrhagic crusting of lips; widespread oral ulcers with ragged margins; labial, buccal mucosa and tongue; "target" lesions of skin

erythema multiforme


diffuse sloughing of the skin and mucosa; F>M; older patients

toxic epidermal necrolysis


common condition of unknown etiology or pathogenesis; correlation with psoriasis is not well established; F>M; transient areas of erythema (papillary atrophy) with yellow-white serpentine borders

geographic tongue


primarily affects the tongue, although any oral mucosal surface may be involved; typically asymptomatic; associated with fissured tongue; munro abcesses; psoriasiform mucositis

geographic tongue


Common chronic mucocutaneous disease; probably immune-mediated; may have only skin, only oral, or both; F>M; adults; skin lesions-purple, polygonal, pruritic papules

lichen planus


oral lesions-reticular or erosive; reticular-interlacing white lines, buccal mucosa; erosive- ulcers with erythema and white streaks; desquamative gingivitis may be seen; any oral mucosal site susceptible

lichen planus


chronic skin disease characterized by an increase in the proliferative activity of keratinocytes, secondary to stimulation from activated T lymphocytes; probably involves both genetic and environmental factors



2nd decade; waxing and waning course with lesions improving during the summer; scalp, elbows, knees; erythematous plaques with silvery scales; psoriatic arthritis; oral lesions are uncommon; munro abcesses



immunologically mediated disease, involving both humoral and cell-mediated immunity; unknown etiology, probably involving both genetic and environmental factors; essentially two varieties-very different prognoses (systemic and chronic cutaneous)

lupus erythematosus


W>M (8:1), 3rd to 4th decade; highly variable presentation; FUO, arthritis, weight loss, fatigue, renal failure; "butterfly rash" over malar region; Libman-Sacks endocarditis; Raynaud's phenomenon; oral ulcerations in 5-25%

systemic lupus erythematosus


W>M (2:1); 4th decade; scaly, erythematous patches on face and scalp; exacerbated by sun exposure; resolve after months with hypo- or hyperpigmentation; oral lesions (10%) resemble erosive LP

chronic cutaneous lupus erythematosus


rare, probably immunologically mediated deposition of collagen within the tissues; while the disease most notably affects the skin, almost all organs and tissues are involved

systemic sclerosis


F>M; adults; skin changes often noted first; "purse string" mouth; acro-osteolysis; skin becomes hard with a smooth texture; "mouse facies"; raynauds phenomenon; dysphagia; radiograph shows diffuse widening of the PDL

systemic sclerosis


possibly a mild variant of systemic sclerosis; calcinosis cutis, raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia

crest syndrome