Development of the Genital System Flashcards Preview

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Flashcards in Development of the Genital System Deck (53):
1

what embryonic origin is the genital system, as well as most of the urinary system

intermediate mesoderm

2

during what week does the lateral body folding of the embryo cause the intermediate mesoderm to go retroperitoneal

week 4

3

the intermediate mesoderm develops a bilateral urogenital ridge (urinary slightly before genital), what are the 2 portions of this ?

-nephrogenic cord
-gonadal ridge

4

which is located more lateral to the midline, the nephrogenic cord or the gonadal ridge

nephrogenic cord

5

what weeks are considered the indifferent stage of sexual development

1-6

6

Which set of ducts are present during the indifferent stage of sexual development
-Mesonephric duct (Wolffian)
-paramesonephrict duct (Mullerian)
-both

Both are present at this time

7

which genital duct gives rise to male structures and which to women ? what are the specific features ?

mesonephric duct ------> vas deferens
paramesonephric duct --------> fallopian tubes

8

what is another name for the mesonephric duct, how about paramesonephric duct

mesonephric duct = Wolffian duct
paramesonephric duct = Mullerian duct

9

at what week can you notice a visible difference b/w male and female sexual development

week 7

10

Primordial germ cells (PGC) begin migrating at week ____ and reach the gonadal ridges at week _____

4, 6

11

what are known as the "welcoming wagons" for the primordial germ cells once they reach the gonadal ridges

Gonadal cord cells

12

what is the embryonic origin of gonadal cord cells

thickened mesothelial lining cells from the gonadal ridge

13

what is the SRY gene and who has it

sex determining region of the Y chromosome
-males

14

what does the SRY gene code for

TDF protein
-testis-determining factor

15

Testes determining factor TDF, stimulates the development of what cells from the mesenchyme of the gonadal ridge

Leydig cells

16

what is the function of Leydig cells and who has them

produce testosterone, men

17

what is the function of Sertoli cells, and who has them

caretakers of the primordial germ cells, men

18

Sertoli cells develop from where

gonadal cord cells after they have enveloped the PGC

19

when the gonadal cord cells envelope the primordial germ cells what two things form ?

seminiferous tubules + Rete testes

20

the superior end of the mesonephric duct eventually develops into what ?

epidiymis

21

the mesonephric tubules eventually develop into what ?

efferent ductules

22

the production of testerone via the Leydig cells stimulates the formation of what

male genial ducts and external genitalia

23

the caudal ends of the mesonephric duct develop into what 2 things

-seminal vesicles
-ejaculatory ducts


24

the very caudal ends of the mesonephric duct continue to develop into the posterior wall of the urinary bladder, this are is called

trigone

25

how do the male accessory organs, the prostate and bulbourethral gland, develop

endodermal outgrowths from the urogenital sinus

26

what hormone do Sertoli cells produce, and what does this hormone do ?

Secretes Mullerian-inhibiting hormone (MIH)
-causes the paramesonephric duct (Mullerian duct) to degernerate in males

27

if there is a little remnant of the Mullerian duct in males from not fully degenerating this is referred to as ?

appendix testis

28

what week does the descent of testis start

week 26

29

how do the testes decend

the gubernaculum ligament shortens which pulls down with it the testis, vas deferens, and testicular vessels

30

where does the gubernaculum ligament extend to

from the gonad to the labioscrotal swelling

31

what does the labioscrotal swelling develop into in males, females ?

males - scrotum
females the labia majora

32

the inferior path of the testis due to the shortening of the gubernaculum ligament is eventually referred to as the

inguinal canal

33

what are the 3 layers of the spermatic cord, and what are they derived from

- internal spermatic fascia (transversalis fascia)
-cremaster fascia (internal oblique m.)
-external spermatic fascia (external oblique m.)

34

what is a hydrocoele of the testis or spermatic cord

fluid filled cyst w/in testis or cord

35

what is a congenital inguinal hernia

outpouching of abdominal viscera which could lead to scrotum

36

what is cryptochidism, and what causes this

failure of testis to descend
-lack of testosterone via Leydig cells

37

what cells of the ovary develop from the mesynchyme of the gonadal cells

Stromal cells

38

what are the equivalent caretakers of the primordial germ cells for females just like sertoli cells in males

follicular cells

39

what causes the mesonephric duct to regress in the development of the female genital systems

Lack of testosterone hormones

40

what causes the continued growth and development of the Mullerian duct in female genital dev.

lack of MIH secreted by sertoli cells

41

what makes up the primordial follice in females

primary oocyte + follicle cell capsule

42

if there are mesonephric duct remnants in the development of female genital systems, this can lead to what 3 things ?

-epoophoron
-paraophoron
-gartner duct cyst

43

the cranial ends of the mullerian ducts form what

uterine tubes/fallopian tubes

44

the caudal ends of the mullerian duct fuse together to form what ?

uterovaginal primordium

45

what does the uterovaginal primordium develop into

the uterus and superior vagina

46

what does the inferior vagina develop from

urogenital sinus

47

what are sinovaginal bulbs

endodermal outgrowths from the urogenital sinus in females which develops into the vaginal plate which leads to the development of inferior vagina

48

the accesory organs of the female genital system consist of the greater vestibular glands, urethral glands, and the paraurethral glands. These all form how

endodermal outgrowths from the urogenital sinus

49

the descent of the ovaries uses the gubernaculum ligament just like males, how is the process different

when is shortens it splits in two because of the development of the uterus

50

what are the derivatives of the gubernaculum ligament in females after it divides via uterus development

superior gubernaculum = ovarian ligament
inferior gubernaculum = round ligament of the uterus

51

what does the genital tubericle develop into in males and females

males - glans penis
female - clit

52

during development the cloacal membrane divides into what 2 folds

urethral fold and anal fold

53

what do the urethral folds develop into in males and females

males - fuse to form shaft of cock
females -remain unfused as labia minor