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Flashcards in Epilepsy CC1 Deck (66)
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1

partial (focal) seizure involves

1 hemisphere

2

generalized (global) seizure involves

both hemispheres

3

simple partial means

1. no LOC

2. single hemisphere

4

complex partial means

1. impairment of conciousness, but can still be awake

2. single hemisphere

5

secondarily generalized means

starts partial, then becomes generalized

6

where do generalzied seizures start?

in subcortical structures

7

abscense seizures involve

loss of consciousness without motor
symptoms. 

8

tonic generlized seizures involves

sustained contraction of muscles

9

clonic seizures involve

repetitive movements (like shaking)

10

tonic clonic seizures involve

start as tonic, then become clonic

11

atonic seizures involve 

negative sx, loss of muscle tone

12

how do you distinguish between complex partial seizure and abscence seizure?

eeg

13

subtypes of generalized seizures

1. abscence

2. tonic

3. clonic

4. tonic-clonic

5. atonic

14

what is epilepsy

the enduring predisposition to generate epileptic seizures

15

idiotpathic seizures are usually

genetic

16

what can cause epileptic channelopathies

mutations in voltage gated ion channels, can cause gain or loss of function

17

what is the inheritance pattern of channelpathies?

what kind of mutations are they mostly?

most are autonosomal dominant

mostly de novo

18

when do febrile seizures occur 

occurring in childhood after 1 month of age

19

what are febrile seizures associated with?

associated with a febrile illness not caused by CNS infection

no hx of previous seizures & not acutely symptomatic

20

febrile seizure is a ___ channelopathy

Na 1.1

21

Generalized Epilepsy with Febrile Seizures Plus invovles mutations in

 SCN1B or SCN1A

22

with Generalized Epilepsy with Febrile Seizures Plus you get a loss of

loss of fast inactivation --> Na channel gain
of function --> persistent Na current

23

with Severe Myoclonic Epilepsy of Infancy  you get a loss of 

 loss of high frequency action potential --> loss of inhibitory
function of GABAergic cortical interneurons & Pukinje cells --> seizures & ataxia

24

signs of Severe Myoclonic Epilepsy of Infancy in first year?

seizures associated with high body temp (fever, bathing) -->
seizures get progressively prolonged and cluster

25

what are the signs of  Severe Myoclonic Epilepsy of Infancy?

show psychomotor delay, ataxia, cognitive impairment

26

what is the range of severity of Na 1.1 channelpathies? 

27

sx of Benign Familial Neonatal Convulsion

brief generalized and partial seizures that usual resolve by age 6 weeks

28

K Channelopathies in Epilepsy invovles loss of function of what receptor?

Loss of Function from mutations in Kv7.2 and Kv7.3

29

K Channelopathies in Epilepsy involve gain of function from 

mutation in the pore-forming subunit 

30

KCNMA1) encodes

the pore formiung suybunit involved in generalized epilepsy & paroxysmal dyskinesia