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Flashcards in Synaptic transmission Lec06 Deck (54)
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1

EPSPs increase the probability for an action potential to be generated because they let _____ into the cell body depolarizing the cell. 

sodium

2

IPSPs decrease the probability for AP by

letting K out or chlorine in

3

direction of electrical synapses

bidirectional

4

electrical synapses are connected via 

gap junctions (made of connexins)

5

what kind of pores do electrical synapses have? what do they let in

 very large pores for unselective ion diffusion

6

what triggers vesicle fusion?

influx of ca through voltage gated ca channels

7

what happens if you have no Ca voltage gated channels

no NT release

8

what happens if you ↓ external [Ca] 

 ↓ # of vesicles = ↓ postsynaptic potential

9

Ionotropic receptors - ligand-gated ion channels respond in ____ 

msec

10

Metabotropic receptors - G-protein-linked receptors that respond in ___

sec/min (growth factor recpeotrs take even longer)

11

how does inactivation of chemical nt take place 

 via reuptake, glial uptake, diffusion, or enzymatic breakdown

12

what are the advantages of chemical synapses 

directionality, amplification, plasticity, summation

13

what is facilitation 

 short-term synaptic plasticity

14

what does facilitation involve?  what does it result in?

 multiple action potentials in a short time (<50 msec) = ↑↑ in synaptic strength

15

describe the 2nd epsp after facilitation 

2nd EPSP larger than the 1st  because Ca clearance is slower than Ca entry into cell

16

how large are small molecule nt

50 nm diameter

17

how are small molecule NT stored?

in clear vesicles

18

some ___ are docked at active zones

small molecule nt

19

docked small molecule nt are released by 

local ca influx

20

how are neuropeptides stored?

dense core vesicles

21

what is required for neuropeptide release? 

high frequency stimulation

22

Vesicle release is quantal/discrete: each vesicle = 

1 mini end plate potential

23

how do miniend plate potentials cause depolarization? 

Many MEPPs make up the endplate potential, EPP, causing depolarization

24

how can you get larger mini end plate potentials?

more ach or more veiscles

25

cable theory

neuron changes in synapse potential decrease with time and space

26

___ and ___ determine probability of an action potential due to leakage

Temporal and spatial summation

27

EPSP & IPSP amplitude & direction depend on 

ion permeability and membrane voltage

28

NMDA is slower, Mg-blocked, but allows ___

Ca entry

29

GABA__ receptors are ligand-gated channels

 A

30

GABA A receptors make __ with CL- ions

fast ipsp