CNS Neurotransmitters Lec05 Flashcards Preview

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Flashcards in CNS Neurotransmitters Lec05 Deck (88)
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1

What are the small molecule NT? *

1. ach.

2. amino acids -- glutamate, gaba, glycine

3. biogenic amines -- dopamine, norepinephrine, serontonin

2

what are the amiunoacid NT?

gaba, gluamate, glycine

3

what are the biogenic amine NT?

dopamine, norepinephrine, serotonin

4

how many different neuropeptides are there

more than 100 different peptides

5

neuropeptides are typically ___ amino acids long 

3-36

6

what are the two major classes of NT?

small moelcule and neuropetides

7

The concentration of neurotransmitter within the synaptic cleft is tightly controlled via regulation of:

synthesis, packaging, release, and removal

8

where are small moelcule NT made?

presynaptic terminal

9

how are small NT packaged into vesicles?

by specific transport proteins in the vesicle membrane

10

where are neuropeptide NT made and packaged?

within the cell body

11

how are vesicles of enruopeptides transported to the nerve terminal?

via fast axonal transport

12

___ neurotransmitters can respond very rapidly?

small molecule

 

are right there in the synaptic terminal to respond quickly

13

___ neurotransmitter release must be carefully regulated to prevent depletion.

neuropeptide

14

ionotropic receptors are ____ gated ion channels that open in response to ligand bonding

ligand gated

15

how many subunits do ionotropic chanels contain? how many transmembrane domains does each subunit contain?

5 subunits; 3-4 transmembrane domains

16

how is diversity established with ionotropic NT?

muleiple subunits are assembled in different orders

17

metabotropic coupled receptors activate ___ in response to ligand binding

g-proteins

18

 activated G-proteins modulate ion channels either

directly or indirectly

19

how many transmembrane domains does each monmeric metabotropic receptor have?

7 transmembrane domains

20

what are the functions of acetylcholine in the CNS?

Attention, arousal, reward plasticity.
Enhances sensory functions upon waking

memory

21

Damage to cholinergic system is associated with the ___

memory defecits in AD

22

where is acetylcholien found in the peripheral NS?

NMJ

synapses in ganglia of the visceral motor system 

23

how is AcH synthesized? 

 enzymatically in nerve terminal from acetyl-CoA and
choline

24

how is acetylcholine removed from the synaptic cleft?

via cleavage to acetate and choline by acetylcholinesterase

25

after degradation, how is more acetylcholine made? 

choline is taken up by nerve terminal via a specific transporter and is used to synthesize more Ach

26

how are Organophosphates such as some insecticides  and nerve gas hamrful to humans?

 inhibit acetylcholinesterase causing ACh to accumulate at cholinergic synapses.

27

what is the result of organophasopates (nerve gases and insectisides) causing acetylcholine build up at the NMJ?

causes muscle paralysis 

28

___ ach receptors mediate most acetylcholine effects in the brain?

metabotropic

29

scopolamine and atropine are

metabotropic achetylcholine anatagonists

30

what are the symptoms of myasthenia gravis?