Flashcards in Exam 1; Pharmacokinetics Deck (20):

1

## This is the study of the effect of the body on a given drug

### pharmacokinetics

2

## Pharmacokinetics is the basis for determining the amount of a drug when

### which remains in the body at any given time after administration

3

## What does Pharmacokinetics allow us to determine

### the proper dose and dosage interval to achieve a desired therapeutic drug concentration

4

## What is the only measurement of drug concentration that can easily be made in humans

### the concentration of a drug in the plasma after administration; assuming the effect of the drug is proportional to its concentration in the blood

5

## What is the α phase

###
the movement from blood to other tissues; redistribution

ignore this phase in pharmacokinetics

6

## What type of graph is the log of serum concentration over hours

### biphasic distribution curve

7

## What is meant by the "first-order kinetics" of the drug concentration

### a constant fraction of the drug is removed per unit of time

8

## What is meant by the "zero-order kinetics" of the drug concentration

### a constant amount of drug is removed per unit of time, regardless of the concentration of the drug (for example; ethanol)

9

## What is the β phase used to calculate

### the half life of the drug

10

## What is the half life of a drug

### the amount of time it takes for the concentration in plasma to decrease by half

11

## The rate of elimination of a drug is proportional to what

### the elimination constant times the amount of drug left

12

## This is the fraction of drug removed per unit of time

### elimination constant (Ke)

13

## What is the fundamental pharmacokinetic equation

### 0.693 = Ke (T½)

14

## This is a value which enables us to predict how much drug must be given to obtain a specific plasma concentration of a drug

### apparent volume of distribution (Vd)

15

## If the drug is taken up by cells, then the initial plasma concentration will be low, what does this say about the apparent volume of distributuon

### it will be very high

16

## amount given (divided by) apparent volume of distribution (equals what)

### plasma concentration at time 0

17

## This is the volume of fluid which is cleared of the drug in unit time

###
drug clearance (CL)

CL = Ke (Vd)

18

## Clearance is the measure of the ability of the body to do what

### eliminate a drug from the blood

19

## After a single dose of a drug, how long will it take for the drug to be 99% eliminated

### 5-6 half lives

20