Flashcards in Exam 4; Immunosuppressants Deck (72)
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1
All of the immunosuppressants carry an increased risk of this
infection
2
Many immunosuppressants cause an increased risk of this
malignancy
3
What are four immunosuppressants that affect T cell activation
atgam
antithymocyte globulin
abatacept
belatacept
4
This agent that affects T cell activation can be used to treat acute renal transplant (polyclonal antibodies)
antithymocyte globulin
5
This agent that affects T cell activation bind to and inhibits CD80 and CD86; used to treat RA
abatacept
6
This agent that affects T cell activation binds to CD80 and CD86, is used in renal transplant and causes an increase in malignancies
belatacept
7
How can you tell which drug is a monoclonal antibody
it ends in -mab
8
The middle (Li or Tu) of a monoclonal antibody drug signifies what
target
Li = immune cell
Tu = tumor cell
9
How can you tell the source of a monoclonal antibody drug
Xi = chimeric source
Zu = humanized
U = fully human
O = fully mouse
10
Which source of a monoclonal antibody is the most antigenic
Xi = chimeric (foreign with human)
O = fully mouse
11
Natalizumab is what kind of monoclonal antibody
immune cell = Li
humanized = zu
12
What is the mechanism behind natalizumab
binds to alpha integrins on the CD4 cell and other immune cell
13
What disease is natalizumab linked with
progressive multi-focal leukoenephalopathy (PML)
fatal viral CNS disease
14
Tocilizumab is what kind a monoclonal antibody
immune cell = Li
fully human = U
15
What is the mechanism behind tocilizumab
bind to IL-6 receptors; T, B, and macrophages
16
Ustekinumab is what kind of monoclonal antibody
immune cell = Li
fully human = U
17
What is the mechanism behind ustekinumab
binds to IL-12 and IL-23
18
Which condition is ustekinumab designed to treat
psoriasis
19
What condition is tocilizumab designed to treat
RA
20
What conditions are natalizumab designed to treat
Crohn's and MS
21
What is the mechanism behind etanercept
binds to TNF itself (binds to an interleukin)
22
What is the route of administration of etanercept
given subQ
23
What is different about etanercept that the other agents that bind to TNF
it is not a monoclonal antibody
24
What disorder is entanercept used to treat
RA
25
Infliximab is what kind of monoclonal antibody
chimeric = Xi
immune cell = Li
26
What is the mechanism behind infliximab
it binds to TNF
27
What disorder is imfliximab used to treat
RA and Crohn's
28
What are two side effects of infliximab
can induce an immune response
if given IV, the infusion can cause itching, hypotension, and fever
29
What is the concern with taking infliximab if you have a pre-existing condition
a pre-existing infection with a fungus or TB will flare up
30
