Exam 4; Immunosuppressants Flashcards Preview

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Flashcards in Exam 4; Immunosuppressants Deck (72)
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1

All of the immunosuppressants carry an increased risk of this

infection

2

Many immunosuppressants cause an increased risk of this

malignancy

3

What are four immunosuppressants that affect T cell activation

atgam
antithymocyte globulin
abatacept
belatacept

4

This agent that affects T cell activation can be used to treat acute renal transplant (polyclonal antibodies)

antithymocyte globulin

5

This agent that affects T cell activation bind to and inhibits CD80 and CD86; used to treat RA

abatacept

6

This agent that affects T cell activation binds to CD80 and CD86, is used in renal transplant and causes an increase in malignancies

belatacept

7

How can you tell which drug is a monoclonal antibody

it ends in -mab

8

The middle (Li or Tu) of a monoclonal antibody drug signifies what

target
Li = immune cell
Tu = tumor cell

9

How can you tell the source of a monoclonal antibody drug

Xi = chimeric source
Zu = humanized
U = fully human
O = fully mouse

10

Which source of a monoclonal antibody is the most antigenic

Xi = chimeric (foreign with human)
O = fully mouse

11

Natalizumab is what kind of monoclonal antibody

immune cell = Li
humanized = zu

12

What is the mechanism behind natalizumab

binds to alpha integrins on the CD4 cell and other immune cell

13

What disease is natalizumab linked with

progressive multi-focal leukoenephalopathy (PML)
fatal viral CNS disease

14

Tocilizumab is what kind a monoclonal antibody

immune cell = Li
fully human = U

15

What is the mechanism behind tocilizumab

bind to IL-6 receptors; T, B, and macrophages

16

Ustekinumab is what kind of monoclonal antibody

immune cell = Li
fully human = U

17

What is the mechanism behind ustekinumab

binds to IL-12 and IL-23

18

Which condition is ustekinumab designed to treat

psoriasis

19

What condition is tocilizumab designed to treat

RA

20

What conditions are natalizumab designed to treat

Crohn's and MS

21

What is the mechanism behind etanercept

binds to TNF itself (binds to an interleukin)

22

What is the route of administration of etanercept

given subQ

23

What is different about etanercept that the other agents that bind to TNF

it is not a monoclonal antibody

24

What disorder is entanercept used to treat

RA

25

Infliximab is what kind of monoclonal antibody

chimeric = Xi
immune cell = Li

26

What is the mechanism behind infliximab

it binds to TNF

27

What disorder is imfliximab used to treat

RA and Crohn's

28

What are two side effects of infliximab

can induce an immune response
if given IV, the infusion can cause itching, hypotension, and fever

29

What is the concern with taking infliximab if you have a pre-existing condition

a pre-existing infection with a fungus or TB will flare up

30

Adalimumab is what kind of monoclonal antibody

immune cell = Li
fully human = U