Exam 1; Administration and Absorption Flashcards Preview

AU14 Pharmacology > Exam 1; Administration and Absorption > Flashcards

Flashcards in Exam 1; Administration and Absorption Deck (21):
1

What are four advantages of oral administration

convenient
acceptable
safe
economical

2

What are four disadvantages of oral administration

unpredictable absorption time
slow onset of action
GI upset and irritation
requires consciousness

3

What are the three routes of parental administration

subcutaneous (slowest)
intramuscular
intravenous (fastest)
- also intraventricular and intrathecal

4

What are three advantages of parental administration

rapid
doesn't require consciousness or cooperation
very predictable dosing

5

What are four disadvantages of parenteral administration

more painful
most costly
danger of infection
essentially irreversible

6

What are six methods of absorption through the skin and mucous membranes

inhalation
cutaneous
rectal (vaginal)
intra-nasal
intra-oral
sublingual

7

What are the four mechanisms of drug entry into cells

passive diffusion**
facilitated diffusion - carrier
active transport
pinocytosis

8

Which sized molecules get through the membrane more readily

small

9

Which type of soluble drugs are more readily absorbed

lipid soluble

10

Which type of molecule does not readily diffuse through the membrane

ionized molecules

11

What is used to predict ionization

the Henderson-Hasselbalch equation

12

As H+ increases, the equation shifts where

to the left; more non-ionized form

13

As H+ decreases, the equation shifts where

to the right; more ionized form

14

The non-ionized form is more soluble in what

lipid (more acidic)

15

The ionized form is more soluble in what

an aqueous environment

16

In formulation, anything other than the drug itself is what

an adjuvant

17

What is a site of non-specific drug binding

proteins in plasma; albumin

18

True or False
Binding is irreversible

False; it is reversible

19

How can non-specific binding effect the drug

effect the ability to get to the target
effect metabolism or execration
may be displaced by other drugs

20

This specific tissue barrier excludes lipid soluble and ionizing drugs

blood-brain

21

This specific tissue berried excludes molecules greater than 1000mw

placental