Exam 4; Glucocorticoids Flashcards Preview

AU14 Pharmacology > Exam 4; Glucocorticoids > Flashcards

Flashcards in Exam 4; Glucocorticoids Deck (15):
1

The synthesis of steroids is essentially via which enzymes

P450s

2

What is the mechanism of action of steroids

enter the target cell and bind to a cytoplasmic receptor

3

The steroid dimerizes, then binds to a response element in the DNA, causing what to occur

either enhance gene transcription or suppress gene transcription

4

Regarding glucocorticouds, this is induced

lipocortin 1

5

What is the function of lipocortin 1

it is an extremely important regulator of the immune system; inhibits phospholipase A2 → decrease in arachniodonic acid → inhibiting the synthesis of prostaglandins and leukotrienes

6

Lipocortin inhibits the synthesis of may what

cytokines, leading to a profound suppression of the immune system

7

What is the immunosuppressive potency, relative mineralcorticoid, and duration of cortisone and hydrocortisone

immunosuppressive potency; 1
relative mineralcorticoid; 1
duration 8-12 hours

8

What is the immunosuppressive potency, relative mineralcorticoid, and duration of prednisone, triamcinolone, and predinisolone

immunosuppressive potency; 4
relative mineralcorticoid; 0.25
duration; 18-36 hours

9

What is the immunosuppressive potency, relative mineralcorticoid, and duration of dexamethasone and betamethasone

immunosuppressive potency; 25
relative mineralcorticoid; <0.01
duration; 36-54 hours

10

What type of drugs are the GCs

pro-drugs; must be metabolized by P450

11

Why are GCs not effective when used topically

topical use can lead to systemic effects

12

What can topical use of GCs be affected by

Dose
Duration of exposure
Potency
Size of area covered
Occlusive dressings
Skin damage
Thickness of the skin

13

What are the side effects of a deficiency of cortisol production

Weight loss
low BP
muscle weakness
Addison's disease

14

What are the side effects of an excess production of cortisol (Cushing's)

adrenal suppression; body is no longer making its of GCs; relying on exogenous GCs, which some from no where; leading to Addison's like symptoms

15

What are the metabolic effects of GCs

Increased liver gluconeogenesis
Decreased glucose uptake by muscle cells
Increased protein breakdown
Decreased protein synthesis
Affects lipolysis; fat redistribution