Exam 3; SE and Treatments Flashcards Preview

AU14 Pharmacology > Exam 3; SE and Treatments > Flashcards

Flashcards in Exam 3; SE and Treatments Deck (64):
1

SE: agranulocytosis

ticlopidine (ADP receptor blocker)

2

SE: anorexia

quinidine (Na+ channel blocker)

3

SE: anti-DUMBBELS (anti-muscarinic)

disopyramide (Na+ channel blocker)

4

SE: anti-vagal effects (2)

quinidine, disopyramide (Na+ channel blockers)

5

SE: asthma

"olol"s (Class II beta blockers)

6

SE: bradycardia

"olol"s (Class II beta blockers)

7

SE: bleeding/hemorrhage (3)

heparin (activates antithrombin)
warfarin (inhibits enzyme)
dabigatran (inhibits thrombin)


8

SE: bleeding after spinal tap/surgery

rivaroxaban, apixaban (inhibits factor Xa)

9

SE: intra-cranial bleeding

vorapaxar (thrombin receptor blocker)

10

SE: prolong bleeding time

thrombolytic agents (convert plasminogen --> plasmin)
ie streptokinase, urokinase, TPA

11

SE: toxic effects on conductive tissues

digoxin (inhibits Na-K-ATPase)

12

SE: optic neuritic

amidorone (K+ channel blocker)

13

SE: cutaneous flusing

niacin (inhibits enzyme, may bind a receptor --> block VLDL synthesis)

14

SE: skin flushing

nitrates (activate guanylate cyclase enzyme)

15

SE: diabetes

niacin (inhibits enzyme, may bind a receptor --> block VLDL synthesis)

16

SE: inc uric acid --> gout

niacin (inhibits enzyme, may bind a receptor --> block VLDL synthesis)

17

SE: hallucinations

digoxin (inhibits Na-K-ATPase)

18

SE: HIT (loss of platelets)

heparin (activates antithrombin)

19

SE: hypotension (2)

GTN (activate guanylate cyclase enzyme)
"olol"s (CLass II beta blockers)

20

SE: itching

niacin (inhibits enzyme, may bind a receptor --> block VLDL synthesis)

21

SE: iodine deposits

amidorone (K+ channel blocker)

22

SE: liver damage (3)

amiodarone (K+ channel blocker - all four)
"statin"s (inhibit HMG-CoA reductase enzyme)
lomitapide (inhibits assembly of VLDL --> hepatotoxicity)

23

SE: lupus-like syndrome

procainamide (Na+ channel blockers)

24

SE: myocardial infarction

"afils" (inhibit Type 5 cGMP phosphodiesterase enzyme)

25

SE: myositis --> rhabomyolsis

"statin"s (inhibit HMG-CoA reductase enzyme)

26

SE: severe nausea

digoxin (inhibits Na-K-ATPase)

27

SE: neural tube defects

folic acid deficiency during pregnancy

28

SE: neural damage (weakness, ataxia, spasticity, irreversible SC damage)

lack of methionine (due to vit B12 deficiency)

29

SE: neutropenia

ticlopidine (ADP receptor blocker)

30

SE: osteoporosis

herparin (activates anti-thrombin)

31

SE: pulmonary fibrosis

amiodarone (K+ channel blocker - all four)

32

SE: excess RBC (--> inc BP, clotting, MI, stroke)

drugs to treat chronic renal failure/chemotherapy (epoietin alfa, darbepoietin, peginesatide)

33

SE: retina damage (NAOIN)

"afil"s (inhibit Type 5 cGMP phosphodiesterase enzyme)

34

SE: severe joint pain

sickle cell anemia (treat with hydroxyurea)

35

SE: spinal hematoma (2)

enoxaparin, dalteparin (low MW heparins - more effect on Xa than thrombin)

36

SE: affects stools (3)

ezetimibe (blocks cholesterol absp from gut)
orlistat (inhibits GI + pancreatic lipase enzyme)
olestra (body cannot absorb oil)

37

SE: stroke (2)

"afil"s (inhibit Type 5 cGMP phosphodiesterase enzyme)
drugs to treat chronic renal failure/chemotherapy (epoietin alfa, darbepoietin, peginesatide)

38

SE: thrombocytopenia (2)

heparin (activates anti-thrombin)
abciximba, tirofiban, eptifibatide (fibrinogen receptor blockers)

39

SE: tinnitus

quinidine (Na+ channel blocker)

40

SE: tremors, seizures

lidocaine (Na+ channel blocker)

41

SE: altered color

quinidine (Na+ channel blocker)

42

SE: blue/green coloration

amiodarone (K+ channel blocker - all four)

43

SE: green/yellow tint

digoxin (inhibits Na-K-ATPase)

44

SE: impaired blue/green color discriminiation

"afil"s (inhibit Type 5 cGMP phosphodiesterase enzyme)

45

SE: disrupt warfarin plasma binding sites

fibrates (bind PPAR - activating receptor)
ie gemfibrozil, fenofibrate

46

Treats: cardiac arrest

amiodarone (K+ channel blocker - all four)

47

Treats: used during coronary operation to decrease white thrombi

abciximba, tirofiban, eptifibatide (fibrinogen receptor blockers) in combo with heparin

48

Treats: heart attack

thrombolytic agents (convert plasminogen --> plasmin)
ie streptokinase, urokinase, TPA

49

Treats: heavy menstruation

hemostatic agents (inhibits plasminogen)
ie aminocaproic acid, transexamic acid

50

Treats: hemophelia

hemostatic agents (inhibits plasminogen)
ie aminocaproic acid, transexamic acid

51

Use these drugs in place of heparin if HIT develops

hirudin (inhibits thrombin enzyme)
bivalirudin, desirudin, agratroban

52

Treats: pulmonary hypertension

"afil"s (inhibit Type 5 cGMP phosphodiesterase enzyme)

53

Treats: atrial tachycardia

adenosine (binds adenosine receptor --> dec AV firing node rate)

54

Treats: ventricular tachycardia

lidocaine (Na+ channel blocker)

55

Treats: micocytic anemia

iron (FeSO4), iron dextran

56

Treats: macrocytic anemia

folic acid

57

Treats: pernicious anemia

B12 injection

58

Treats: anemia due to chronic renal failure/chemotherapy

epoietin alfa, darbepoietin, peginesatide

59

Treats: sickle cell anemia

hydroxyurea

60

1st pass metabolism

lidocaine, GTN

61

enhance effects in hypokalemia

digoxin

62

P450

"afil"s
warfarin
"statin"s

63

can cross placenta

fondaparinux
warfarin (FDA Cat X)
hydroxyurea (FDA Cat D)
"statin"s (FDA Cat X)

64

SE: dec absorption of fat soluble vitamins

cholestyramine, coleselevam, colestipol (bile acid binding proteins)