Granulomatosis with polyangiitis

Question 1

What is the former name of granulomatosis with polyangiitis?

Answer 1

Wegener granulomatosis

This term is important for historical context and understanding of the disease.

Question 2

What are the three components of the triad associated with granulomatosis with polyangiitis?

Answer 2

• Hematuria
• Hemoptysis
• Head-itis (e.g., nasal septal perforation, mastoiditis, sinusitis, otitis)

This triad is crucial for diagnosing the condition in adults.

Question 3

Which antibodies are associated with granulomatosis with polyangiitis?

Answer 3

• cANCA
• Anti-proteinase 3 (anti-PR3) antibodies

These antibodies play a significant role in the autoimmune aspect of the disease.

Question 4

What type of glomerulonephritis is caused by granulomatosis with polyangiitis?

Answer 4

Necrotizing glomerulonephritis

This condition can lead to rapidly progressive glomerulonephritis (RPGN).

Question 5

True or False: Granulomatosis with polyangiitis can lead to rapidly progressive glomerulonephritis.

Answer 5

True

This highlights the serious nature of the disease and its potential complications.