Osteosarcoma

Question 1

What is the most common primary bone cancer?

Answer 1

Osteosarcoma

Osteosarcoma typically occurs in patients aged 10-30.

Question 2

Which genetic mutations are associated with osteosarcoma?

Answer 2

RB mutations (congenital retinoblastoma)

For example, a 1-year-old boy with enucleation of the eye for retinoblastoma is at risk of developing osteosarcoma later in life.

Question 3

What is a key imaging finding associated with osteosarcoma?

Answer 3

Codman triangle and Sunburst appearance

These findings are characteristic of the disease.

Question 4

What does Codman triangle refer to?

Answer 4

Periosteal reaction with lifting of periosteum off the bone

This is a classic radiographic finding in osteosarcoma.

Question 5

What is the Sunburst appearance in osteosarcoma?

Answer 5

Periosteal reaction described as spiculated new bone formation

This appearance is also noted in radiographic assessments.

Question 6

Answer 6

The white arrow is the Codman triangle; the white star is the sunburst appearance.