BRCA

Question 1

What type of genes are BRCA1 and BRCA2?

Answer 1

Tumor suppressor genes

BRCA1 and BRCA2 play a crucial role in maintaining genomic stability.

Question 2

How are BRCA1 and BRCA2 inherited?

Answer 2

Autosomal dominant fashion with incomplete penetrance

This means that the trait may not appear in every generation.

Question 3

What molecular process is affected by BRCA mutations?

Answer 3

Recombinational double-stranded DNA repair

This process is essential for repairing DNA breaks and maintaining genomic integrity.

Question 4

What is the next best step for women with confirmed BRCA mutations?

Answer 4

Bilateral mastectomy and oophorectomy

This surgical intervention significantly reduces the risk of breast and ovarian cancer.

Question 5

True or False: BRCA mutations can skip a generation.

Answer 5

True

This is due to the incomplete penetrance associated with these mutations.